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Mouse Anti-LSR Recombinant Antibody (A944) (CBMAB-AP4295LY)

The product is antibody recognizes LSR. The antibody A944 immunoassay techniques such as: ICC, IHC, IP, WB.
See all LSR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A944
Antibody Isotype
IgG
Application
ICC, IHC, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LSR
Entrez Gene ID
51599
UniProt ID
Q86X29
Alternative Names
LISCH7, ILDR3, LISCH, Lipolysis-Stimulated Remnant, Immunoglobulin-Like Domain Containing Receptor 3
Function
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).
Biological Process
Epithelial structure maintenanceISS:UniProtKB
Establishment of blood-brain barrierISS:ARUK-UCL
Establishment of skin barrierISS:ARUK-UCL
Liver developmentISS:HGNC
Maintenance of blood-brain barrier1 PublicationNAS:ARUK-UCL
Protein localization to tricellular tight junctionISS:ARUK-UCL
Tricellular tight junction assemblyISS:ARUK-UCL
Cellular Location
Cell membrane
Cell junction, tight junction
Located at tricellular contacts.
Topology
Extracellular: 1-259
Helical: 260-280
Cytoplasmic: 281-649
PTM
Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions.

Funauchi, M., Serada, S., Hiramatsu, K., Funajima, E., Kanda, M., Nagase, Y., ... & Naka, T. (2023). Tumor cell‐expressed lipolysis‐stimulated lipoprotein receptor negatively regulates T‐cell function. International Journal of Cancer.

Kanda, M., Serada, S., Hiramatsu, K., Funauchi, M., Obata, K., Nakagawa, S., ... & Naka, T. (2023). Lipolysis-stimulated lipoprotein receptor-targeted antibody-drug conjugate demonstrates potent antitumor activity against epithelial ovarian cancer. Neoplasia, 35, 100853.

Herzine, A., Sekkat, G., Kaminski, S., Calcagno, G., Boschi-Muller, S., Safi, H., ... & Yen, F. T. (2022). Lipolysis-stimulated lipoprotein receptor acts as sensor to regulate ApoE release in astrocytes. International Journal of Molecular Sciences, 23(15), 8630.

Nagase, Y., Hiramatsu, K., Funauchi, M., Shiomi, M., Masuda, T., Kakuda, M., ... & Kimura, T. (2022). Anti-lipolysis-stimulated lipoprotein receptor monoclonal antibody as a novel therapeutic agent for endometrial cancer. BMC cancer, 22(1), 679.

Dong, X., Zhang, X., Liu, P., Tian, Y., Li, L., & Gong, P. (2022). Lipolysis-Stimulated Lipoprotein Receptor Impairs Hepatocellular Carcinoma and Inhibits the Oncogenic Activity of YAP1 via PPPY Motif. Frontiers in Oncology, 12, 896412.

Wang, J., Qin, M., Wu, Q., Yang, H., Wei, B., Xie, J., ... & Huang, J. (2022). Effects of lipolysis-stimulated lipoprotein receptor on tight junctions of pancreatic ductal epithelial cells in hypertriglyceridemic acute pancreatitis. BioMed Research International, 2022.

Shimada, H., Kohno, T., Konno, T., Okada, T., Saito, K., Shindo, Y., ... & Kojima, T. (2021). The roles of tricellular tight junction protein angulin-1/lipolysis-stimulated lipoprotein receptor (LSR) in endometriosis and endometrioid-endometrial carcinoma. Cancers, 13(24), 6341.

Chen, Y., Zhang, S., Dai, H., Hong, Z., & Lin, Y. (2020). A multiple mixed TiO2 mesocrystal junction based PEC-colorimetric immunoassay for specific recognition of lipolysis stimulated lipoprotein receptor. Biosensors and Bioelectronics, 148, 111809.

El Hajj, A., Yen, F. T., Oster, T., Malaplate, C., Pauron, L., Corbier, C., ... & Claudepierre, T. (2019). Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain. PloS one, 14(6), e0218812.

Kohno, T., Konno, T., & Kojima, T. (2019). Role of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor (LSR) in cancer cells. International Journal of Molecular Sciences, 20(14), 3555.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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