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Rabbit Anti-LSR Recombinant Antibody (CBYCL-515) (CBMAB-L0416-YC)


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Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
CBYCL-515
Antibody Isotype
IgG
Application
WB, IP, IHC-P

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LSR
Introduction
LSR (Lipolysis Stimulated Lipoprotein Receptor) is a protein coding gene. Diseases associated with LSR include Deafness, Autosomal Recessive 42 and Deafness, Autosomal Recessive 49. Among its related pathways are Lipoprotein metabolism and Metabolism. And an important paralog is ILDR2. LSR probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells.
Entrez Gene ID
Human51599
Monkey106994738
UniProt ID
HumanQ86X29
MonkeyA0A2K5WNB1
Alternative Names
ILDR3; LISCH7
Function
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).
Biological Process
Epithelial structure maintenanceISS:UniProtKB
Establishment of blood-brain barrierISS:ARUK-UCL
Establishment of skin barrierISS:ARUK-UCL
Liver developmentISS:HGNC
Maintenance of blood-brain barrier1 PublicationNAS:ARUK-UCL
Protein localization to tricellular tight junctionISS:ARUK-UCL
Tricellular tight junction assemblyISS:ARUK-UCL
Cellular Location
Cell membrane
Cell junction, tight junction
Located at tricellular contacts.
Topology
Extracellular: 1-259
Helical: 260-280
Cytoplasmic: 281-649
PTM
Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions.
More Infomation

Funauchi, M., Serada, S., Hiramatsu, K., Funajima, E., Kanda, M., Nagase, Y., ... & Naka, T. (2023). Tumor cell‐expressed lipolysis‐stimulated lipoprotein receptor negatively regulates T‐cell function. International Journal of Cancer.

Kanda, M., Serada, S., Hiramatsu, K., Funauchi, M., Obata, K., Nakagawa, S., ... & Naka, T. (2023). Lipolysis-stimulated lipoprotein receptor-targeted antibody-drug conjugate demonstrates potent antitumor activity against epithelial ovarian cancer. Neoplasia, 35, 100853.

Herzine, A., Sekkat, G., Kaminski, S., Calcagno, G., Boschi-Muller, S., Safi, H., ... & Yen, F. T. (2022). Lipolysis-stimulated lipoprotein receptor acts as sensor to regulate ApoE release in astrocytes. International Journal of Molecular Sciences, 23(15), 8630.

Nagase, Y., Hiramatsu, K., Funauchi, M., Shiomi, M., Masuda, T., Kakuda, M., ... & Kimura, T. (2022). Anti-lipolysis-stimulated lipoprotein receptor monoclonal antibody as a novel therapeutic agent for endometrial cancer. BMC cancer, 22(1), 679.

Dong, X., Zhang, X., Liu, P., Tian, Y., Li, L., & Gong, P. (2022). Lipolysis-Stimulated Lipoprotein Receptor Impairs Hepatocellular Carcinoma and Inhibits the Oncogenic Activity of YAP1 via PPPY Motif. Frontiers in Oncology, 12, 896412.

Wang, J., Qin, M., Wu, Q., Yang, H., Wei, B., Xie, J., ... & Huang, J. (2022). Effects of lipolysis-stimulated lipoprotein receptor on tight junctions of pancreatic ductal epithelial cells in hypertriglyceridemic acute pancreatitis. BioMed Research International, 2022.

Shimada, H., Kohno, T., Konno, T., Okada, T., Saito, K., Shindo, Y., ... & Kojima, T. (2021). The roles of tricellular tight junction protein angulin-1/lipolysis-stimulated lipoprotein receptor (LSR) in endometriosis and endometrioid-endometrial carcinoma. Cancers, 13(24), 6341.

Chen, Y., Zhang, S., Dai, H., Hong, Z., & Lin, Y. (2020). A multiple mixed TiO2 mesocrystal junction based PEC-colorimetric immunoassay for specific recognition of lipolysis stimulated lipoprotein receptor. Biosensors and Bioelectronics, 148, 111809.

El Hajj, A., Yen, F. T., Oster, T., Malaplate, C., Pauron, L., Corbier, C., ... & Claudepierre, T. (2019). Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain. PloS one, 14(6), e0218812.

Kohno, T., Konno, T., & Kojima, T. (2019). Role of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor (LSR) in cancer cells. International Journal of Molecular Sciences, 20(14), 3555.

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For research use only. Not intended for any clinical use.

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