Mouse Lsr ELISA Kit (V2LY-0626-LY2529)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.0053 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
66.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
LSR
Function
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).
Biological Process
Epithelial structure maintenanceISS:UniProtKB
Establishment of blood-brain barrierISS:ARUK-UCL
Establishment of skin barrierISS:ARUK-UCL
Liver developmentISS:HGNC
Maintenance of blood-brain barrier1 PublicationNAS:ARUK-UCL
Protein localization to tricellular tight junctionISS:ARUK-UCL
Tricellular tight junction assemblyISS:ARUK-UCL
Cellular Location
Cell membrane
Cell junction, tight junction
Located at tricellular contacts.
Topology
Extracellular: 1-259
Helical: 260-280
Cytoplasmic: 281-649
PTM
Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions.

Funauchi, M., Serada, S., Hiramatsu, K., Funajima, E., Kanda, M., Nagase, Y., ... & Naka, T. (2023). Tumor cell‐expressed lipolysis‐stimulated lipoprotein receptor negatively regulates T‐cell function. International Journal of Cancer.

Kanda, M., Serada, S., Hiramatsu, K., Funauchi, M., Obata, K., Nakagawa, S., ... & Naka, T. (2023). Lipolysis-stimulated lipoprotein receptor-targeted antibody-drug conjugate demonstrates potent antitumor activity against epithelial ovarian cancer. Neoplasia, 35, 100853.

Herzine, A., Sekkat, G., Kaminski, S., Calcagno, G., Boschi-Muller, S., Safi, H., ... & Yen, F. T. (2022). Lipolysis-stimulated lipoprotein receptor acts as sensor to regulate ApoE release in astrocytes. International Journal of Molecular Sciences, 23(15), 8630.

Nagase, Y., Hiramatsu, K., Funauchi, M., Shiomi, M., Masuda, T., Kakuda, M., ... & Kimura, T. (2022). Anti-lipolysis-stimulated lipoprotein receptor monoclonal antibody as a novel therapeutic agent for endometrial cancer. BMC cancer, 22(1), 679.

Dong, X., Zhang, X., Liu, P., Tian, Y., Li, L., & Gong, P. (2022). Lipolysis-Stimulated Lipoprotein Receptor Impairs Hepatocellular Carcinoma and Inhibits the Oncogenic Activity of YAP1 via PPPY Motif. Frontiers in Oncology, 12, 896412.

Wang, J., Qin, M., Wu, Q., Yang, H., Wei, B., Xie, J., ... & Huang, J. (2022). Effects of lipolysis-stimulated lipoprotein receptor on tight junctions of pancreatic ductal epithelial cells in hypertriglyceridemic acute pancreatitis. BioMed Research International, 2022.

Shimada, H., Kohno, T., Konno, T., Okada, T., Saito, K., Shindo, Y., ... & Kojima, T. (2021). The roles of tricellular tight junction protein angulin-1/lipolysis-stimulated lipoprotein receptor (LSR) in endometriosis and endometrioid-endometrial carcinoma. Cancers, 13(24), 6341.

Chen, Y., Zhang, S., Dai, H., Hong, Z., & Lin, Y. (2020). A multiple mixed TiO2 mesocrystal junction based PEC-colorimetric immunoassay for specific recognition of lipolysis stimulated lipoprotein receptor. Biosensors and Bioelectronics, 148, 111809.

El Hajj, A., Yen, F. T., Oster, T., Malaplate, C., Pauron, L., Corbier, C., ... & Claudepierre, T. (2019). Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain. PloS one, 14(6), e0218812.

Kohno, T., Konno, T., & Kojima, T. (2019). Role of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor (LSR) in cancer cells. International Journal of Molecular Sciences, 20(14), 3555.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human LSR ELISA Kit (CAT#: V2LY-0626-LY4817)

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Human LSR ELISA Kit (CAT#: V2LY-0626-LY4817)

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Mouse Anti-LSR Recombinant Antibody (CBYCL-513) (CAT#: CBMAB-L0414-YC)

Rabbit Anti-LSR Recombinant Antibody (CBYCL-515) (CAT#: CBMAB-L0416-YC)

Isotype control

For research use only. Not intended for any clinical use.

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