LTB4R

Diseases associated with LTB4R include Specific Language Impairment and Asthma. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is LTB4R2. Receptor for extracellular ATP> UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. It may be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. LTB4R is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Full Name
Leukotriene B4 Receptor
Function
Receptor for extracellular ATP> UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Biological Process
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-19
Helical: 20-42
Cytoplasmic: 43-54
Helical: 55-75
Extracellular: 76-91
Helical: 92-113
Cytoplasmic: 114-138
Helical: 139-159
Extracellular: 160-178
Helical: 179-199
Cytoplasmic: 200-221
Helical: 222-242
Extracellular: 243-268
Helical: 269-289
Cytoplasmic: 290-352
PTM
Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.
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Anti-LTB4R antibodies

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Mouse Anti-LTB4R Recombinant Antibody (CBYCL-530) (CBMAB-L0431-YC)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCL-530
Application*: IH
Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYCL-528) (CBMAB-L0429-YC)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCL-528
Application*: F, C
Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYCL-527) (CBMAB-L0428-YC)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-527
Application*: F, IH
Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2146) (CBMAB-L2320-YJ)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2146
Application*: F
Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2145) (CBMAB-L2319-YJ)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2145
Application*: F, WB
Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2144) (CBMAB-L2318-YJ)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2144
Application*: WB
Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2143) (CBMAB-L2317-YJ)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2143
Application*: F
Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2141) (CBMAB-L2313-YJ)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2141
Application*: F
Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (203/14F11) (CBMAB-L2312-YJ)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 203/14F11
Application*: F
Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2140) (CBMAB-L2311-YJ)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2140
Application*: C, F
Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (202/7B1) (CBMAB-L2310-YJ)

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Target: LTB4R
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 202/7B1
Application*: F, IH, IC, IF, C
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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