LTB4R

Diseases associated with LTB4R include Specific Language Impairment and Asthma. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is LTB4R2. Receptor for extracellular ATP> UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. It may be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. LTB4R is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Full Name

Leukotriene B4 Receptor

Function

Receptor for extracellular ATP> UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Biological Process

G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-19
Helical: 20-42
Cytoplasmic: 43-54
Helical: 55-75
Extracellular: 76-91
Helical: 92-113
Cytoplasmic: 114-138
Helical: 139-159
Extracellular: 160-178
Helical: 179-199
Cytoplasmic: 200-221
Helical: 222-242
Extracellular: 243-268
Helical: 269-289
Cytoplasmic: 290-352

PTM

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.

Anti-LTB4R antibodies

+ Filters

Human LTB4R ELISA Kit (V2LY-0626-LY1970)

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Target: LTB4R

Sensitivity: 0.093 ng/mL

Detection Range: 0.2-70 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Datasheet SDS

Rat Ltb4r ELISA Kit (V2LY-0626-LY1282)

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Target: Ltb4r

Sensitivity: 0.17 ng/mL

Detection Range: 0.38-24 ng/mL

Sample Type: Serum, Plasma, Urine, Ascites, Cerebrospinal fluid, Tissue

Specificity: Rat

Assay Type: Sandwich

Reactivity: Rat

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYCL-530) (CBMAB-L0431-YC)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYCL-530

Application*: IH

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYCL-528) (CBMAB-L0429-YC)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYCL-528

Application*: F, C

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYCL-527) (CBMAB-L0428-YC)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCL-527

Application*: F, IH

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2146) (CBMAB-L2320-YJ)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-2146

Application*: F

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2145) (CBMAB-L2319-YJ)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2145

Application*: F, WB

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2144) (CBMAB-L2318-YJ)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2144

Application*: WB

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2143) (CBMAB-L2317-YJ)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2143

Application*: F

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2141) (CBMAB-L2313-YJ)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-2141

Application*: F

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (203/14F11) (CBMAB-L2312-YJ)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 203/14F11

Application*: F

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2140) (CBMAB-L2311-YJ)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-2140

Application*: C, F

Datasheet SDS

Mouse Anti-LTB4R Recombinant Antibody (202/7B1) (CBMAB-L2310-YJ)

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Target: LTB4R

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 202/7B1

Application*: F, IH, IC, IF, C

Datasheet SDS

More Infomation

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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