Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2141) (CBMAB-L2313-YJ)

Name: Mouse Anti-LTB4R Recombinant Antibody (CBYJL-2141)
SKU: CBMAB-L2313-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-2141

Application

Immunogen

HeLa cell transfectants expressing human BLTR.

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Preservative

0.09% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Leukotriene B4 Receptor

Introduction

Diseases associated with LTB4R include Specific Language Impairment and Asthma. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is LTB4R2.Receptor for extracellular ATP> UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. It may be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. LTB4R is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Entrez Gene ID

1241

UniProt ID

Q15722

Alternative Names

Leukotriene B4 Receptor; Chemoattractant Receptor-Like 1; P2Y Purinoceptor 7; LTB4-R 1; LTB4-R1; CMKRL1; GPR16; P2RY7; BLT1; BLTR

Function

Receptor for extracellular ATP> UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Biological Process

G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-19
Helical: 20-42
Cytoplasmic: 43-54
Helical: 55-75
Extracellular: 76-91
Helical: 92-113
Cytoplasmic: 114-138
Helical: 139-159
Extracellular: 160-178
Helical: 179-199
Cytoplasmic: 200-221
Helical: 222-242
Extracellular: 243-268
Helical: 269-289
Cytoplasmic: 290-352

PTM

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.

Nie, J., Ai, J., Hong, W., Bai, Z., Wang, B., Yang, J., ... & Wei, X. (2023). Cisplatin‐induced oxPAPC release enhances MDSCs infiltration into LL2 tumour tissues through MCP‐1/CCL2 and LTB4/LTB4R pathways. Cell Proliferation, e13570.

Zhang, X., Wu, H., Yan, X., Ma, J., & Chen, Z. (2022). LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway. Cells, 11(22), 3606.

Zhang, X., Liu, P., Liu, K., Li, W., Chen, Q., & Ma, W. (2022). Prognostic implications and functional enrichment analysis of LTB4R in patients with acute myeloid leukemia. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 42(3), 309-320.

Long, S., Ji, S., Xiao, K., Xue, P., & Zhu, S. (2021). Prognostic and immunological value of LTB4R in pan-cancer. Mathematical Biosciences and Engineering, 18(6), 9336-9356.

Wu, H. H., Yan, X., Chen, Z., Du, G. W., Bai, X. J., Tuoheti, K., & Liu, T. Z. (2021). GNRH1 and LTB4R might be novel immune-related prognostic biomarkers in clear cell renal cell carcinoma (ccRCC). Cancer cell international, 21(1), 1-14.

Kalinkin, A. I., Sigin, V. O., Nemtsova, M. V., Kuznetsova, E. B., Kekeeva, T. V., Vinogradov, I. Y., ... & Tanas, A. S. (2021). Abnormal demethylation and ectopic expression of leukotriene receptors genes LTB4R/LTB4R2 in breast cancer. Medical Genetics, 20(8), 21-30.

Kalinkin, A. I., Sigin, V. O., Tanas, A. S., & Strelnikov, V. V. (2020). 17P Cyclophosphamide influence on survival probability of breast cancer patients depending on leukotriene receptor LTB4R gene expression level. Annals of Oncology, 31, S1222.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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