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Mouse Anti-LTB4R Recombinant Antibody (202/7B1) (CBMAB-L2310-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leukotriene B4 Receptor (LTB4R). The antibody can be used for immunoassay techniques, such as FC, IHC, ICC, IF, IHC-Fr.
See all LTB4R antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
202/7B1
Antibody Isotype
IgG2a
Application
FC, IHC, ICC, IF, IHC-Fr

Basic Information

Immunogen
HeLa cell transfectants expressing human BLTR.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Leukotriene B4 Receptor
Introduction
Diseases associated with LTB4R include Specific Language Impairment and Asthma. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is LTB4R2.Receptor for extracellular ATP> UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. It may be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. LTB4R is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Entrez Gene ID
1241
UniProt ID
Q15722
Alternative Names
Leukotriene B4 Receptor; Chemoattractant Receptor-Like 1; P2Y Purinoceptor 7; LTB4-R 1; LTB4-R1; CMKRL1; GPR16; P2RY7; BLT1; BLTR
Function
Receptor for extracellular ATP> UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Biological Process
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-19
Helical: 20-42
Cytoplasmic: 43-54
Helical: 55-75
Extracellular: 76-91
Helical: 92-113
Cytoplasmic: 114-138
Helical: 139-159
Extracellular: 160-178
Helical: 179-199
Cytoplasmic: 200-221
Helical: 222-242
Extracellular: 243-268
Helical: 269-289
Cytoplasmic: 290-352
PTM
Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.

Nie, J., Ai, J., Hong, W., Bai, Z., Wang, B., Yang, J., ... & Wei, X. (2023). Cisplatin‐induced oxPAPC release enhances MDSCs infiltration into LL2 tumour tissues through MCP‐1/CCL2 and LTB4/LTB4R pathways. Cell Proliferation, e13570.

Zhang, X., Wu, H., Yan, X., Ma, J., & Chen, Z. (2022). LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway. Cells, 11(22), 3606.

Zhang, X., Liu, P., Liu, K., Li, W., Chen, Q., & Ma, W. (2022). Prognostic implications and functional enrichment analysis of LTB4R in patients with acute myeloid leukemia. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 42(3), 309-320.

Long, S., Ji, S., Xiao, K., Xue, P., & Zhu, S. (2021). Prognostic and immunological value of LTB4R in pan-cancer. Mathematical Biosciences and Engineering, 18(6), 9336-9356.

Wu, H. H., Yan, X., Chen, Z., Du, G. W., Bai, X. J., Tuoheti, K., & Liu, T. Z. (2021). GNRH1 and LTB4R might be novel immune-related prognostic biomarkers in clear cell renal cell carcinoma (ccRCC). Cancer cell international, 21(1), 1-14.

Kalinkin, A. I., Sigin, V. O., Nemtsova, M. V., Kuznetsova, E. B., Kekeeva, T. V., Vinogradov, I. Y., ... & Tanas, A. S. (2021). Abnormal demethylation and ectopic expression of leukotriene receptors genes LTB4R/LTB4R2 in breast cancer. Medical Genetics, 20(8), 21-30.

Kalinkin, A. I., Sigin, V. O., Tanas, A. S., & Strelnikov, V. V. (2020). 17P Cyclophosphamide influence on survival probability of breast cancer patients depending on leukotriene receptor LTB4R gene expression level. Annals of Oncology, 31, S1222.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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