Human LTB4R ELISA Kit (V2LY-0626-LY1970)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.093 ng/mL
Detection Range
0.2-70 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
37.6 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Leukotriene B4 Receptor
Function
Receptor for extracellular ATP> UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Biological Process
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-19
Helical: 20-42
Cytoplasmic: 43-54
Helical: 55-75
Extracellular: 76-91
Helical: 92-113
Cytoplasmic: 114-138
Helical: 139-159
Extracellular: 160-178
Helical: 179-199
Cytoplasmic: 200-221
Helical: 222-242
Extracellular: 243-268
Helical: 269-289
Cytoplasmic: 290-352
PTM
Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.

Nie, J., Ai, J., Hong, W., Bai, Z., Wang, B., Yang, J., ... & Wei, X. (2023). Cisplatin‐induced oxPAPC release enhances MDSCs infiltration into LL2 tumour tissues through MCP‐1/CCL2 and LTB4/LTB4R pathways. Cell Proliferation, e13570.

Zhang, X., Wu, H., Yan, X., Ma, J., & Chen, Z. (2022). LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway. Cells, 11(22), 3606.

Zhang, X., Liu, P., Liu, K., Li, W., Chen, Q., & Ma, W. (2022). Prognostic implications and functional enrichment analysis of LTB4R in patients with acute myeloid leukemia. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 42(3), 309-320.

Long, S., Ji, S., Xiao, K., Xue, P., & Zhu, S. (2021). Prognostic and immunological value of LTB4R in pan-cancer. Mathematical Biosciences and Engineering, 18(6), 9336-9356.

Wu, H. H., Yan, X., Chen, Z., Du, G. W., Bai, X. J., Tuoheti, K., & Liu, T. Z. (2021). GNRH1 and LTB4R might be novel immune-related prognostic biomarkers in clear cell renal cell carcinoma (ccRCC). Cancer cell international, 21(1), 1-14.

Kalinkin, A. I., Sigin, V. O., Nemtsova, M. V., Kuznetsova, E. B., Kekeeva, T. V., Vinogradov, I. Y., ... & Tanas, A. S. (2021). Abnormal demethylation and ectopic expression of leukotriene receptors genes LTB4R/LTB4R2 in breast cancer. Medical Genetics, 20(8), 21-30.

Kalinkin, A. I., Sigin, V. O., Tanas, A. S., & Strelnikov, V. V. (2020). 17P Cyclophosphamide influence on survival probability of breast cancer patients depending on leukotriene receptor LTB4R gene expression level. Annals of Oncology, 31, S1222.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Ltb4r ELISA Kit (CAT#: V2LY-0626-LY1282)

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Rat Ltb4r ELISA Kit (CAT#: V2LY-0626-LY1282)

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Isotype control

For research use only. Not intended for any clinical use.

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