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MFGE8

This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Full Name

Milk Fat Globule-EGF Factor 8 Protein

Function

Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity).

Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.

Medin:
Main constituent of aortic medial amyloid.

Biological Process

Angiogenesis Source: UniProtKB-KW
Apoptotic cell clearance Source: Ensembl
Cell adhesion Source: UniProtKB-KW
Phagocytosis, engulfment Source: Ensembl
Phagocytosis, recognition Source: Ensembl
Positive regulation of phagocytosis Source: Ensembl
Single fertilization Source: UniProtKB-KW

Cellular Location

Secreted
Other locations
Membrane
acrosome membrane
Note: Located in the acrosomal region of zona-pellucida bound sperm.

PTM

Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.

Anti-MFGE8 antibodies

Rat Anti-MFGE8 (AA 23-463) Recombinant Antibody (CBFYM-2151) (CBMAB-M2333-FY)

SDS

Target: MFGE8

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYM-2151

Application*: ED, WB

Hamster Anti-MFGE8 Recombinant Antibody (CBFYM-2150) (CBMAB-M2332-FY)

SDS

Target: MFGE8

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYM-2150

Application*: F, IP

Hamster Anti-MFGE8 Recombinant Antibody (CBFYM-2149) (CBMAB-M2331-FY)

SDS

Target: MFGE8

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYM-2149

Application*: C, WB

Mouse Anti-MFGE8 Recombinant Antibody (CBFYM-2148) (CBMAB-M2330-FY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2148

Application*: F, IF, C

Mouse Anti-MFGE8 Recombinant Antibody (CBFYM-2147) (CBMAB-M2329-FY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-2147

Application*: E, P

Mouse Anti-MFGE8 Recombinant Antibody (CBFYM-2146) (CBMAB-M2328-FY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-2146

Application*: IC, C, P, WB

Mouse Anti-MFGE8 (AA 61-170) Recombinant Antibody (CBFYM-2145) (CBMAB-M2327-FY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-2145

Application*: E, IP, WB

Mouse Anti-MFGE8 Recombinant Antibody (CBFYM-2143) (CBMAB-M2325-FY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-2143

Application*: E, WB

Mouse Anti-MFGE8 Recombinant Antibody (CBFYM-0629) (CBMAB-M0764-FY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-0629

Application*: IF, IH, IP, WB

Mouse Anti-MFGE8 Recombinant Antibody (CBFYM-0628) (CBMAB-M0763-FY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0628

Application*: IH

Mouse Anti-MFGE8 Recombinant Antibody (CBFYM-0274) (CBMAB-M0339-FY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-0274

Application*: P, IP, WB

Mouse Anti-MFGE8 (AA 24-387) Recombinant Antibody (CBFYM-0104) (CBMAB-M0117-FY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-0104

Application*: F

Hamster Anti-Mfge8 Recombinant Antibody (CBYJL-2410) (CBMAB-L2733-YJ)

SDS

Target: Mfge8

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJL-2410

Application*: FC, IP

Hamster Anti-Mfge8 Recombinant Antibody (CBYJL-2409) (CBMAB-L2732-YJ)

SDS

Target: Mfge8

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJL-2409

Application*: C, WB

Mouse Anti-MFGE8 Recombinant Antibody (CBYJL-265) (CBMAB-L0370-YJ)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-265

Application*: E, P, IP, WB

Mouse Anti-MFGE8 Recombinant Antibody (CBYJL-264) (CBMAB-L0369-YJ)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-264

Application*: E, WB, P, IP

Mouse Anti-MFGE8 Recombinant Antibody (CBYJL-263) (CBMAB-L0368-YJ)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-263

Application*: IC, C, P, WB

Mouse Anti-MFGE8 Recombinant Antibody (CBYJL-262) (CBMAB-L0367-YJ)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-262

Application*: WB, P, C, IF, IC

Mouse Anti-MFGE8 Recombinant Antibody (CBYJL-261) (CBMAB-L0366-YJ)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-261

Application*: C, E, IC, IF, WB, P

Mouse Anti-MFGE8 Recombinant Antibody (CBYJL-260) (CBMAB-L0364-YJ)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-260

Application*: E, IP, P, WB

Mouse Anti-MFGE8 Recombinant Antibody (A1078) (CBMAB-AP4454LY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: A1078

Application*: ELISA, IHC

Mouse Anti-MFGE8 Recombinant Antibody (A1077) (CBMAB-AP4487LY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1077

Application*: FC, IF, IHC

Mouse Anti-MFGE8 Recombinant Antibody (A1076) (CBMAB-AP4481LY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1076

Application*: FC, IF, IHC

Mouse Anti-MFGE8 Recombinant Antibody (A1075) (CBMAB-AP4488LY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1075

Application*: FC, IF, IHC

Mouse Anti-MFGE8 Recombinant Antibody (CB323A) (CBMAB-CA323LY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CB323A

Application*: ELISA, IHC

Mouse Anti-MFGE8 Recombinant Antibody (3E9) (CBMAB-A5442-LY)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3E9

Application*: WB, E

Mouse Anti-MFGE8 Recombinant Antibody (2B2D10) (CBMAB-R4231-CN)

SDS

Target: MFGE8

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2B2D10

Application*: E, IH

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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