MFGE8
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Full Name
Milk Fat Globule-EGF Factor 8 Protein
Function
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity).
Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.
Medin:
Main constituent of aortic medial amyloid.
Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.
Medin:
Main constituent of aortic medial amyloid.
Biological Process
Angiogenesis Source: UniProtKB-KW
Apoptotic cell clearance Source: Ensembl
Cell adhesion Source: UniProtKB-KW
Phagocytosis, engulfment Source: Ensembl
Phagocytosis, recognition Source: Ensembl
Positive regulation of phagocytosis Source: Ensembl
Single fertilization Source: UniProtKB-KW
Apoptotic cell clearance Source: Ensembl
Cell adhesion Source: UniProtKB-KW
Phagocytosis, engulfment Source: Ensembl
Phagocytosis, recognition Source: Ensembl
Positive regulation of phagocytosis Source: Ensembl
Single fertilization Source: UniProtKB-KW
Cellular Location
Secreted
Other locations
Membrane
acrosome membrane
Note: Located in the acrosomal region of zona-pellucida bound sperm.
Other locations
Membrane
acrosome membrane
Note: Located in the acrosomal region of zona-pellucida bound sperm.
PTM
Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.
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Anti-MFGE8 antibodies
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CompareTarget: MFGE8
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYM-2150
Application*: F, IP
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-265
Application*: E, P, IP, WB
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-264
Application*: E, WB, P, IP
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-263
Application*: IC, C, P, WB
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-262
Application*: WB, P, C, IF, IC
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-261
Application*: C, E, IC, IF, WB, P
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-260
Application*: E, IP, P, WB
Target: Mfge8
Sensitivity: 0.0094 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Mfge8
Sensitivity: 0.242 ng/mL
Detection Range: 0.5-200 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: MFGE8
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-387
Tag: His Tag
Target: MFGE8
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-387
Tag: His & AVI Tag
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1078
Application*: ELISA, IHC
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1077
Application*: FC, IF, IHC
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1076
Application*: FC, IF, IHC
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1075
Application*: FC, IF, IHC
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB323A
Application*: ELISA, IHC
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E9
Application*: WB, E
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2B2D10
Application*: E, IH
Target: MFGE8
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-2151
Application*: ED, WB
Target: MFGE8
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYM-2149
Application*: C, WB
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2148
Application*: F, IF, C
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2147
Application*: E, P
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2146
Application*: IC, C, P, WB
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2145
Application*: E, IP, WB
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2143
Application*: E, WB
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0629
Application*: IF, IH, IP, WB
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0628
Application*: IH
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0274
Application*: P, IP, WB
Target: MFGE8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0104
Application*: F
Target: Mfge8
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJL-2410
Application*: FC, IP
Target: Mfge8
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJL-2409
Application*: C, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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