Hamster Anti-Mfge8 Recombinant Antibody (CBYJL-2409) (CBMAB-L2732-YJ)

Name: Hamster Anti-Mfge8 Recombinant Antibody (CBYJL-2409)
SKU: CBMAB-L2732-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Hamster

Clone

CBYJL-2409

Application

IHC-Fr, WB

Specificity

Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Milk Fat Globule-EGF Factor 8 Protein

Introduction

It contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. It also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction (By similarity). It plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization.

Entrez Gene ID

17304

UniProt ID

P21956

Alternative Names

P47; MP47; Mfgm; SED1; MFG-E8; AA408458; AI325141; lactadherin; lactadherin; EGF/factor VIII; milk fat globule glycoprotein; sperm surface protein SP47

Function

Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity).

Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.

Medin:
Main constituent of aortic medial amyloid.

Biological Process

Angiogenesis Source: UniProtKB-KW
Apoptotic cell clearance Source: Ensembl
Cell adhesion Source: UniProtKB-KW
Phagocytosis, engulfment Source: Ensembl
Phagocytosis, recognition Source: Ensembl
Positive regulation of phagocytosis Source: Ensembl
Single fertilization Source: UniProtKB-KW

Cellular Location

Secreted
Other locations
Membrane
acrosome membrane
Note: Located in the acrosomal region of zona-pellucida bound sperm.

PTM

Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.

Liu, B., Zhang, B., Qi, J., Zhou, H., Tan, L., Huang, J., ... & Guan, X. Y. (2023). Targeting MFGE8 secreted by cancer-associated fibroblasts blocks angiogenesis and metastasis in esophageal squamous cell carcinoma. Proceedings of the National Academy of Sciences, 120(42), e2307914120.

Ruotsalainen, S. E., Surakka, I., Mars, N., Karjalainen, J., Kurki, M., Kanai, M., ... & Southerington, T. (2022). Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis. Communications biology, 5(1), 802.

Wang, J., Wang, Y., Zuo, Y., Duan, J., Pan, A., Li, J. M., ... & Liu, F. (2021). MFGE8 mitigates brain injury in a rat model of SAH by maintaining vascular endothelial integrity via TIGβ5/PI3K/CXCL12 signaling. Experimental Brain Research, 239(7), 2193-2205.

Tian, J., Wang, V., Wang, N., Khadang, B., Boudreault, J., Bakdounes, K., ... & Lebrun, J. J. (2021). Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. Breast Cancer Research, 23(1), 1-18.

Lim, H., Yang, T., Lee, W., & Park, S. G. (2021). TGF-β Increases MFGE8 production in myeloid-derived suppressor cells to promote B16F10 melanoma metastasis. Biomedicines, 9(8), 896.

Wang, B., Ge, Z., Wu, Y., Zha, Y., Zhang, X., Yan, Y., & Xie, Y. (2020). MFGE8 is down‐regulated in cardiac fibrosis and attenuates endothelial‐mesenchymal transition through Smad2/3‐Snail signalling pathway. Journal of cellular and molecular medicine, 24(21), 12799-12812.

Ni, Y. Q., Zhan, J. K., & Liu, Y. S. (2020). Roles and mechanisms of MFG-E8 in vascular aging-related diseases. Ageing Research Reviews, 64, 101176.

Ge, Z., Chen, Y., Wang, B., Zhang, X., Yan, Y., Zhou, L., ... & Xie, Y. (2020). MFGE8 attenuates Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation through inhibition of TGF-β1/Smad2/3 pathway. Journal of molecular and cellular cardiology, 139, 164-175.

Cheyuo, C., Aziz, M., & Wang, P. (2019). Neurogenesis in neurodegenerative diseases: role of MFG-E8. Frontiers in neuroscience, 13, 569.

Soubeyrand, S., Nikpay, M., Turner, A., Dang, A. T., Herfkens, M., Lau, P., & McPherson, R. (2019). Regulation of MFGE8 by the intergenic coronary artery disease locus on 15q26. 1. Atherosclerosis, 284, 11-17.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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