MICAL1

This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Full Name

Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 1

Function

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822).

In the absence of actin, it also functions as a NADPH oxidase producing H2O2 (PubMed:21864500, PubMed:26845023, PubMed:29343822).

Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity).

May act as Rab effector protein and play a role in vesicle trafficking.

Biological Process

Actin filament bundle assembly Source: GO_Central
Actin filament depolymerization Source: UniProtKB
Cytoskeleton organization Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Regulation of regulated secretory pathway Source: Ensembl
Signal transduction Source: UniProtKB
Sulfur oxidation Source: UniProtKB

Cellular Location

Cytoskeleton
Cytoplasm
Other locations
Midbody
Note: Accumulates transiently at the abscission site before abscission occurs.