MKRN2

This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Makorin Ring Finger Protein 2

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity).

Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity).

Plays a role in the regulation of spermiation and in male fertility (By similarity).

Negative regulation of inflammatory response to antigenic stimulus Source: UniProtKB
Negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription factor catabolic process Source: UniProtKB
Protein kinase B signaling Source: UniProtKB
Protein polyubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Transcription, DNA-templated Source: UniProtKB

Cytoplasm
Nucleus