MKRN2

This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Full Name
Makorin Ring Finger Protein 2
Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity).

Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity).

Plays a role in the regulation of spermiation and in male fertility (By similarity).
Biological Process
Negative regulation of inflammatory response to antigenic stimulus Source: UniProtKB
Negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription factor catabolic process Source: UniProtKB
Protein kinase B signaling Source: UniProtKB
Protein polyubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Transcription, DNA-templated Source: UniProtKB
Cellular Location
Cytoplasm
Nucleus
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Anti-MKRN2 antibodies

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Mouse Anti-MKRN2 Recombinant Antibody (A1116) (CBMAB-AP11861LY)

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Target: MKRN2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1116
Application*: FC, IHC, WB
Datasheet SDS

Recombinant Mouse Anti-MKRN2 Antibody (CBAb166) (CBMAB-Ab166-LY)

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Target: MKRN2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb166
Application*: WB, IH, FC
Datasheet SDS

Mouse Anti-MKRN2 (AA 317-416) Recombinant Antibody (CBFYM-2267) (CBMAB-M2452-FY)

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Target: MKRN2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2267
Application*: IF, WB
Datasheet SDS

Mouse Anti-MKRN2 Recombinant Antibody (CBFYM-0652) (CBMAB-M0788-FY)

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Target: MKRN2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0652
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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