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Mouse Anti-MKRN2 Recombinant Antibody (CBFYM-0652) (CBMAB-M0788-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0652
Antibody Isotype
IgG1, k
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Makorin Ring Finger Protein 2
Introduction
This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
23609
UniProt ID
Q9H000
Alternative Names
Makorin Ring Finger Protein 2; RING-Type E3 Ubiquitin Transferase Makorin-2; RING Finger Protein 62; RNF62; Probable E3 Ubiquitin-Protein Ligase Makorin-2; Makorin RING Zinc-Finger Protein 2; EC 2.3.2.27; HSPC070
Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity).

Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity).

Plays a role in the regulation of spermiation and in male fertility (By similarity).
Biological Process
Negative regulation of inflammatory response to antigenic stimulus Source: UniProtKB
Negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription factor catabolic process Source: UniProtKB
Protein kinase B signaling Source: UniProtKB
Protein polyubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Transcription, DNA-templated Source: UniProtKB
Cellular Location
Cytoplasm
Nucleus
More Infomation

Wang, L., Yong, Y. L., Wang, K. K., Xie, Y. X., Qian, Y. C., Zhou, F. M., ... & Jiang, B. H. (2023). MKRN2 knockout causes male infertility through decreasing STAT1, SIX4, and TNC expression. Frontiers in Endocrinology, 14, 1138096.

Jiang, F. Z., Xia, Q. J., Wu, L., & Zhang, Y. M. (2023). Overexpression of MKRN2 Inhibits the Growth of Ovarian Cancer Cells. Molecular Biology, 1-8.

Qi, P., Yexie, Z., Xue, C., Huang, G., Zhao, Z., & Zhang, X. (2023). LINC00294/miR-620/MKRN2 axis provides biomarkers and negatively regulates malignant progression in colorectal carcinoma. Human & Experimental Toxicology, 42, 09603271231167577.

Bonazza, S., Coutts, H., Sukumar, S., Turkington, H., & Courtney, D. G. (2023). Identifying cellular RNA-binding proteins during infection uncovers a role for MKRN2 in influenza mRNA trafficking. bioRxiv, 2023-10.

Liu, Z., Xiang, S., Guo, X., Zhou, J., Liao, L., Kou, J., & Zhang, J. (2022). MKRN2 inhibits the proliferation of gastric cancer by downregulating PKM2. Aging (Albany NY), 14(4), 2004.

Wolf, E. J., Miles, A., Lee, E. S., Nabeel-Shah, S., Greenblatt, J. F., Palazzo, A. F., ... & Emili, A. (2020). MKRN2 physically interacts with GLE1 to regulate mRNA export and zebrafish retinal development. Cell Reports, 31(8).

Jia, C., Tang, H., Yang, Y., Yuan, S., Han, T., Fang, M., ... & Geng, W. (2020). Ubiquitination of IGF2BP3 by E3 ligase MKRN2 regulates the proliferation and migration of human neuroblastoma SHSY5Y cells. Biochemical and Biophysical Research Communications, 529(1), 43-50.

Qian, Y. C., Xie, Y. X., Wang, C. S., Shi, Z. M., Jiang, C. F., Tang, Y. Y., ... & Jiang, B. H. (2020). Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis. Asian Journal of Andrology, 22(4), 414.

Zhang, Y., Cui, N., & Zheng, G. (2020). Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation. Oncology Letters, 19(3), 1975-1984.

Wang, Q., Han, C. L., Wang, K. L., Sui, Y. P., Li, Z. B., Chen, N., ... & Meng, F. G. (2020). Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc‐MKRN2‐42: 1 in the pathogenesis of Parkinson's disease. CNS neuroscience & therapeutics, 26(5), 527-537.

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For research use only. Not intended for any clinical use.

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