Sign in or Register

MLXIPL

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq]
Full Name
MLX interacting protein-like
Function
Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Energy homeostasis Source: UniProtKB
Fatty acid homeostasis Source: UniProtKB
Glucose homeostasis Source: BHF-UCL
Glucose mediated signaling pathway Source: BHF-UCL
Negative regulation of oxidative phosphorylation Source: BHF-UCL
Negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of fatty acid biosynthetic process Source: BHF-UCL
Positive regulation of glycolytic process Source: BHF-UCL
Positive regulation of lipid biosynthetic process Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription, DNA-templated Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Triglyceride homeostasis Source: BHF-UCL
Cellular Location
Nucleus
Involvement in disease
WBSCR14 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
PTM
Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity.
View more

Anti-MLXIPL antibodies

+ Filters
Loading...

Mouse Anti-MLXIPL Recombinant Antibody (CBT4758) (V2LY-0625-LY32)

Go to compareCompare
Target: MLXIPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4758
Application*: IC
Datasheet SDS

Mouse Anti-MLXIPL Recombinant Antibody (5B2) (CBMAB-A5526-LY)

Go to compareCompare
Target: MLXIPL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5B2
Application*: SE, E
Datasheet SDS

Mouse Anti-MLXIPL Recombinant Antibody (CBXC-1727) (CBMAB-C5776-CQ)

Go to compareCompare
Target: MLXIPL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1727
Application*: WB, IF, E
Datasheet SDS

Mouse Anti-MLXIPL Recombinant Antibody (CBXC-2738) (CBMAB-C0135-CQ)

Go to compareCompare
Target: MLXIPL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-2738
Application*: WB, IH, IF, P
Datasheet SDS

Mouse Anti-MLXIPL (AA 603-700) Recombinant Antibody (CBFYM-2318) (CBMAB-M2503-FY)

Go to compareCompare
Target: MLXIPL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2318
Application*: E
Datasheet SDS

Mouse Anti-MLXIPL (AA 18-143) Recombinant Antibody (CBFYM-2317) (CBMAB-M2502-FY)

Go to compareCompare
Target: MLXIPL
Host: Mouse
Specificity: Human
Clone: CBFYM-2317
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-MLXIPL Recombinant Antibody (5D12D1) (CBMAB-C7448-LY)

Go to compareCompare
Target: MLXIPL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5D12D1
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-MLXIPL Recombinant Antibody (2D9NB) (CBMAB-C0872-LY)

Go to compareCompare
Target: MLXIPL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2D9NB
Application*: WB, IH, IC/IF, P
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry