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Mouse Anti-MLXIPL Recombinant Antibody (2D9NB) (CBMAB-C0872-LY)

This product is antibody recognizes MLXIPL. The antibody 2D9NB immunoassay techniques such as: WB, IHC, ICC/IF, IHC-P.
See all MLXIPL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D9NB
Antibody Isotype
IgG2b, κ
Application
WB, IHC, ICC/IF, IHC-P

Basic Information

Immunogen
Partial recombinant human ChREBP protein between amino acids 600-800. [UniProt Q9NP71]
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MLX interacting protein-like
Introduction
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Entrez Gene ID
51085
UniProt ID
Q9NP71
Alternative Names
MLX Interacting Protein Like; Williams-Beuren Syndrome Chromosomal Region 14 Protein; WS Basic-Helix-Loop-Helix Leucine Zipper Protein; Carbohydrate Response Element Binding Protein; Williams Beuren Syndrome Chromosome Region 14; Class D Basic Helix-Loop-Helix Protein 14; WBSCR14; WS-BHLH; BHLHd14; CHREBP; MIO;
Function
Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Energy homeostasis Source: UniProtKB
Fatty acid homeostasis Source: UniProtKB
Glucose homeostasis Source: BHF-UCL
Glucose mediated signaling pathway Source: BHF-UCL
Negative regulation of oxidative phosphorylation Source: BHF-UCL
Negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of fatty acid biosynthetic process Source: BHF-UCL
Positive regulation of glycolytic process Source: BHF-UCL
Positive regulation of lipid biosynthetic process Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription, DNA-templated Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Triglyceride homeostasis Source: BHF-UCL
Cellular Location
Nucleus
Involvement in disease
WBSCR14 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
PTM
Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity.

Chang, X., Tian, C., Jia, Y., Cai, Y., & Yan, P. (2023). MLXIPL promotes the migration, invasion, and glycolysis of hepatocellular carcinoma cells by phosphorylation of mTOR. BMC cancer, 23(1), 1-9.

Loika, Y., Loiko, E., Feng, F., Stallard, E., Yashin, A. I., Arbeev, K., ... & Kulminski, A. M. (2023). Exogenous exposures shape genetic predisposition to lipids, Alzheimer's, and coronary heart disease in the MLXIPL gene locus.

Maldonado-González, M., Hernández-Nazara, Z. H., Torres-Castillo, N., Martínez-López, E., De La Cruz-Color, L., & Ruíz-Madrigal, B. (2022). Association between the rs3812316 Single Nucleotide Variant of the MLXIPL Gene and Alpha-Linolenic Acid Intake with Triglycerides in Mexican Mestizo Women. Nutrients, 14(22), 4726.

Dong, X., Wang, F., Liu, C., Ling, J., Jia, X., Shen, F., ... & Li, Q. (2021). Single-cell analysis reveals the intra-tumor heterogeneity and identifies MLXIPL as a biomarker in the cellular trajectory of hepatocellular carcinoma. Cell death discovery, 7(1), 14.

Wang, H., Cao, Y., Shu, L., Zhu, Y., Peng, Q., Ran, L., ... & Fan, J. (2020). Long non‐coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes. Journal of Cellular and Molecular Medicine, 24(2), 1399-1412.

Zhan, H., Wang, Y., Yu, S., Cai, G., Zeng, Y., Ma, J., ... & Wu, W. (2020). Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation. Aging (Albany NY), 12(11), 11004.

Vorobelová, L., Danková, Z., Candráková-Cernanová, V., Falbová, D., Cvícelová, M., Benuš, R., & Siváková, D. (2019). Association of the ESR1 polymorphism with menopause and MLXIPL genetic variant influence serum uric acid levels in Slovak midlife women. Menopause, 26(10), 1185-1192.

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For research use only. Not intended for any clinical use.

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