MSRA

This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Methionine Sulfoxide Reductase A

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Cellular protein modification process Source: ProtInc
Cellular response to oxidative stress Source: GO_Central
Methionine metabolic process Source: ProtInc
Protein repair Source: Reactome
Response to oxidative stress Source: ProtInc

Isoform 1:
Mitochondrion
Isoform 2:
Cytoplasm
Isoform 3:
Cytoplasm
Nucleus
Isoform 5:
Cytoplasm
Other locations
Membrane