Mouse Anti-MSRA (AA 1-100) Recombinant Antibody (CBFYM-2667) (CBMAB-M2856-FY)

Name: Mouse Anti-MSRA (AA 1-100) Recombinant Antibody (CBFYM-2667)
SKU: CBMAB-M2856-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2667

Application

ELISA, IHC, WB

Immunogen

Partial recombinant corresponding to aa1-100 from human MSRA (NP_036463.1) with GST tag. MW of the GST tag alone is 26kD.

Specificity

Human

Antibody Isotype

IgM, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-100

More Infomation

Target

Full Name

Methionine Sulfoxide Reductase A

Introduction

This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

4482

UniProt ID

Q9UJ68

Alternative Names

Methionine Sulfoxide Reductase A; Peptide-Methionine (S)-S-Oxide Reductase; Peptide Met(O) Reductase; EC 1.8.4.11; PMSR; Mitochondrial Peptide Methionine Sulfoxide Reductase; Cytosolic Methionine-S-Sulfoxide Reductase; Protein-Methionine-S-Oxide Reductase; Peptide Met (O) Reductase

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Biological Process

Cellular protein modification process Source: ProtInc
Cellular response to oxidative stress Source: GO_Central
Methionine metabolic process Source: ProtInc
Protein repair Source: Reactome
Response to oxidative stress Source: ProtInc

Cellular Location

Isoform 1:
Mitochondrion
Isoform 2:
Cytoplasm
Isoform 3:
Cytoplasm
Nucleus
Isoform 5:
Cytoplasm
Other locations
Membrane

Thyne, K. M., & Salmon, A. B. (2022). Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA). Scientific reports, 12(1), 5073.

Chen, Y., Zhao, M., Lv, M., Lin, M., Wang, J., & Zuo, K. (2022). A Novel Small RNA, DsrO, in Deinococcus radiodurans Promotes Methionine Sulfoxide Reductase (msrA) Expression for Oxidative Stress Adaptation. Applied and Environmental Microbiology, 88(11), e00038-22.

Nair, S. S., Chauhan, T. K. S., Kumawat, M., Sarkhel, R., Apoorva, S., Shome, A., ... & Mahawar, M. (2021). Deletion of both methionine sulfoxide reductase A and methionine sulfoxide reductase C genes renders Salmonella Typhimurium highly susceptible to hypochlorite stress and poultry macrophages. Molecular Biology Reports, 48(4), 3195-3203.

Duport, C., Madeira, J. P., Farjad, M., Alpha-Bazin, B., & Armengaud, J. (2021). Methionine sulfoxide reductases contribute to anaerobic fermentative metabolism in Bacillus cereus. Antioxidants, 10(5), 819.

Tarrago, L., Grosse, S., Lemaire, D., Faure, L., Tribout, M., Siponen, M. I., ... & Sabaty, M. (2020). Reduction of protein bound methionine sulfoxide by a periplasmic dimethyl sulfoxide reductase. Antioxidants, 9(7), 616.

Oien, D. B., & Moskovitz, J. (2019). Genetic regulation of longevity and age-associated diseases through the methionine sulfoxide reductase system. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1865(7), 1756-1762.

Reiterer, M., Schmidt-Kastner, R., & Milton, S. L. (2019). Methionine sulfoxide reductase (Msr) dysfunction in human brain disease. Free radical research, 53(11-12), 1144-1154.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

MSRA Matched Antibody Pair (759) (CAT#: APMAB-759LY)

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Mouse Anti-MSRA Recombinant Antibody (CBFYM-2666) (CAT#: CBMAB-M2855-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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