Human MSRA ELISA Kit (V2LY-0626-LY4895)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.058 ng/mL
Detection Range
0.1-40 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
26.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Methionine Sulfoxide Reductase A
Function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Biological Process
Cellular protein modification process Source: ProtInc
Cellular response to oxidative stress Source: GO_Central
Methionine metabolic process Source: ProtInc
Protein repair Source: Reactome
Response to oxidative stress Source: ProtInc
Cellular Location
Isoform 1:
Mitochondrion
Isoform 2:
Cytoplasm
Isoform 3:
Cytoplasm
Nucleus
Isoform 5:
Cytoplasm
Other locations
Membrane

Thyne, K. M., & Salmon, A. B. (2022). Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA). Scientific reports, 12(1), 5073.

Chen, Y., Zhao, M., Lv, M., Lin, M., Wang, J., & Zuo, K. (2022). A Novel Small RNA, DsrO, in Deinococcus radiodurans Promotes Methionine Sulfoxide Reductase (msrA) Expression for Oxidative Stress Adaptation. Applied and Environmental Microbiology, 88(11), e00038-22.

Nair, S. S., Chauhan, T. K. S., Kumawat, M., Sarkhel, R., Apoorva, S., Shome, A., ... & Mahawar, M. (2021). Deletion of both methionine sulfoxide reductase A and methionine sulfoxide reductase C genes renders Salmonella Typhimurium highly susceptible to hypochlorite stress and poultry macrophages. Molecular Biology Reports, 48(4), 3195-3203.

Duport, C., Madeira, J. P., Farjad, M., Alpha-Bazin, B., & Armengaud, J. (2021). Methionine sulfoxide reductases contribute to anaerobic fermentative metabolism in Bacillus cereus. Antioxidants, 10(5), 819.

Tarrago, L., Grosse, S., Lemaire, D., Faure, L., Tribout, M., Siponen, M. I., ... & Sabaty, M. (2020). Reduction of protein bound methionine sulfoxide by a periplasmic dimethyl sulfoxide reductase. Antioxidants, 9(7), 616.

Oien, D. B., & Moskovitz, J. (2019). Genetic regulation of longevity and age-associated diseases through the methionine sulfoxide reductase system. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1865(7), 1756-1762.

Reiterer, M., Schmidt-Kastner, R., & Milton, S. L. (2019). Methionine sulfoxide reductase (Msr) dysfunction in human brain disease. Free radical research, 53(11-12), 1144-1154.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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