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Mouse Anti-MSRA Recombinant Antibody (CBFYM-2666) (CBMAB-M2855-FY)

This product is mouse antibody that recognizes MSRA. The antibody CBFYM-2666 can be used for immunoassay techniques such as: IHC, IP.
See all MSRA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2666
Antibody Isotype
IgG2b, k
Application
IHC, IP

Basic Information

Immunogen
Recombinant human protein purified from E.coli
Specificity
Human
Antibody Isotype
IgG2b, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Methionine Sulfoxide Reductase A
Introduction
This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
4482
UniProt ID
Q9UJ68
Alternative Names
Methionine Sulfoxide Reductase A; Peptide-Methionine (S)-S-Oxide Reductase; Peptide Met(O) Reductase; EC 1.8.4.11; PMSR; Mitochondrial Peptide Methionine Sulfoxide Reductase; Cytosolic Methionine-S-Sulfoxide Reductase; Protein-Methionine-S-Oxide Reductase; Peptide Met (O) Reductase
Function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Biological Process
Cellular protein modification process Source: ProtInc
Cellular response to oxidative stress Source: GO_Central
Methionine metabolic process Source: ProtInc
Protein repair Source: Reactome
Response to oxidative stress Source: ProtInc
Cellular Location
Isoform 1:
Mitochondrion
Isoform 2:
Cytoplasm
Isoform 3:
Cytoplasm
Nucleus
Isoform 5:
Cytoplasm
Other locations
Membrane

Thyne, K. M., & Salmon, A. B. (2022). Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA). Scientific reports, 12(1), 5073.

Chen, Y., Zhao, M., Lv, M., Lin, M., Wang, J., & Zuo, K. (2022). A Novel Small RNA, DsrO, in Deinococcus radiodurans Promotes Methionine Sulfoxide Reductase (msrA) Expression for Oxidative Stress Adaptation. Applied and Environmental Microbiology, 88(11), e00038-22.

Nair, S. S., Chauhan, T. K. S., Kumawat, M., Sarkhel, R., Apoorva, S., Shome, A., ... & Mahawar, M. (2021). Deletion of both methionine sulfoxide reductase A and methionine sulfoxide reductase C genes renders Salmonella Typhimurium highly susceptible to hypochlorite stress and poultry macrophages. Molecular Biology Reports, 48(4), 3195-3203.

Duport, C., Madeira, J. P., Farjad, M., Alpha-Bazin, B., & Armengaud, J. (2021). Methionine sulfoxide reductases contribute to anaerobic fermentative metabolism in Bacillus cereus. Antioxidants, 10(5), 819.

Tarrago, L., Grosse, S., Lemaire, D., Faure, L., Tribout, M., Siponen, M. I., ... & Sabaty, M. (2020). Reduction of protein bound methionine sulfoxide by a periplasmic dimethyl sulfoxide reductase. Antioxidants, 9(7), 616.

Oien, D. B., & Moskovitz, J. (2019). Genetic regulation of longevity and age-associated diseases through the methionine sulfoxide reductase system. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1865(7), 1756-1762.

Reiterer, M., Schmidt-Kastner, R., & Milton, S. L. (2019). Methionine sulfoxide reductase (Msr) dysfunction in human brain disease. Free radical research, 53(11-12), 1144-1154.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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