NASP

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.

Full Name

nuclear autoantigenic sperm protein (histone-binding)

Function

Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.

Biological Process

Blastocyst development Source: UniProtKB
CENP-A containing chromatin assembly Source: GO_Central
DNA replication Source: UniProtKB-KW
DNA replication-dependent chromatin assembly Source: UniProtKB
DNA replication-independent chromatin assembly Source: UniProtKB
G1/S transition of mitotic cell cycle Source: UniProtKB
Histone exchange Source: UniProtKB
Male gonad development Source: Ensembl
Nucleosome assembly Source: UniProtKB
Protein transport Source: UniProtKB-KW
Response to testosterone Source: Ensembl

Cellular Location

Nucleus
Cytoplasm