NASP

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.
Full Name
nuclear autoantigenic sperm protein (histone-binding)
Function
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Biological Process
Blastocyst development Source: UniProtKB
CENP-A containing chromatin assembly Source: GO_Central
DNA replication Source: UniProtKB-KW
DNA replication-dependent chromatin assembly Source: UniProtKB
DNA replication-independent chromatin assembly Source: UniProtKB
G1/S transition of mitotic cell cycle Source: UniProtKB
Histone exchange Source: UniProtKB
Male gonad development Source: Ensembl
Nucleosome assembly Source: UniProtKB
Protein transport Source: UniProtKB-KW
Response to testosterone Source: Ensembl
Cellular Location
Nucleus
Cytoplasm
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Anti-NASP antibodies

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Rabbit Anti-NASP Recombinant Antibody (CBWJN-1175) (CBMAB-N1209-WJ)

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Target: NASP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJN-1175
Application*: WB, IP, F, IC
Datasheet SDS

Mouse Anti-NASP Recombinant Antibody (A-7) (CBMAB-N1208-WJ)

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Target: NASP
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: A-7
Application*: WB, IP, IF, E
Datasheet SDS

Cattle NASP ELISA Kit (V2LY-0626-LY597)

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Target: NASP
Sensitivity: 0.15 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Datasheet SDS

Human NASP ELISA Kit (V2LY-0626-LY4198)

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Target: NASP
Sensitivity: 0.0097 ng/mL
Detection Range: 0.02-3.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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