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NFE2

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Full Name
Nuclear Factor, Erythroid 2
Function
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Biological Process
Hemostasis Source: ProtInc
Integrated stress response signaling Source: ComplexPortal
Multicellular organism development Source: ProtInc
Nucleosome disassembly Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PML body
Cytoplasm
Note: The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
PTM
Phosphorylated on serine residues. In undifferentiated erythrocytes, phosphorylated by MAPK8 which then leads to ubiquitination and protein degradation.
Sumoylated. Sumoylation is required for translocation to nuclear bodies PODs, anchoring to the gene loci, and transactivation of the beta-globin gene.
Ubiquitinated mainly by 'Lys63'-linked ubiquitin. Polyubiquitination with 'Lys63'-linked ubiquitin by ITCH retains NFE2 in the cytoplasm preventing its transactivation activity. In undifferentiated erythrocyte, ubiquitinated after MAPK8-mediatd phosphorylation leading to protein degradation (By similarity).
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Anti-NFE2 antibodies

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Mouse Anti-NFE2 Recombinant Antibody (A1333) (CBMAB-AP12590LY)

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Target: NFE2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1333
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-NFE2 Recombinant Antibody (CB468A) (CBMAB-CA468LY)

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Target: NFE2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB468A
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-NFE2 Recombinant Antibody (G-2) (CBMAB-N2187-WJ)

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Target: NFE2
Host: Mouse
Specificity: Human
Clone: G-2
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NFE2 Recombinant Antibody (D-6) (CBMAB-N2185-WJ)

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Target: NFE2
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: D-6
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NFE2 Recombinant Antibody (2C6) (CBMAB-N2184-WJ)

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Target: NFE2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C6
Application*: E, WB
Datasheet SDS

Mouse Anti-NFE2 Recombinant Antibody (1D7C8) (CBMAB-N2183-WJ)

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Target: NFE2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D7C8
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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