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NFE2

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

Full Name

Nuclear Factor, Erythroid 2

Function

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

Biological Process

Hemostasis Source: ProtInc
Integrated stress response signaling Source: ComplexPortal
Multicellular organism development Source: ProtInc
Nucleosome disassembly Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus
PML body
Cytoplasm
Note: The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.

PTM

Phosphorylated on serine residues. In undifferentiated erythrocytes, phosphorylated by MAPK8 which then leads to ubiquitination and protein degradation.
Sumoylated. Sumoylation is required for translocation to nuclear bodies PODs, anchoring to the gene loci, and transactivation of the beta-globin gene.
Ubiquitinated mainly by 'Lys63'-linked ubiquitin. Polyubiquitination with 'Lys63'-linked ubiquitin by ITCH retains NFE2 in the cytoplasm preventing its transactivation activity. In undifferentiated erythrocyte, ubiquitinated after MAPK8-mediatd phosphorylation leading to protein degradation (By similarity).

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Anti-NFE2 antibodies

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Mouse Anti-NFE2 Recombinant Antibody (A1333) (CBMAB-AP12590LY)

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Target: NFE2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: A1333

Application*: ELISA, WB

Mouse Anti-NFE2 Recombinant Antibody (CB468A) (CBMAB-CA468LY)

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Target: NFE2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CB468A

Application*: ELISA, WB

Mouse Anti-NFE2 Recombinant Antibody (G-2) (CBMAB-N2187-WJ)

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Target: NFE2

Host: Mouse

Specificity: Human

Clone: G-2

Application*: WB, IP, IF, E

Mouse Anti-NFE2 Recombinant Antibody (D-6) (CBMAB-N2185-WJ)

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Target: NFE2

Host: Mouse

Specificity: Human, Mouse, Rat

Clone: D-6

Application*: WB, IP, IF, E

Mouse Anti-NFE2 Recombinant Antibody (2C6) (CBMAB-N2184-WJ)

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Target: NFE2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2C6

Application*: E, WB

Mouse Anti-NFE2 Recombinant Antibody (1D7C8) (CBMAB-N2183-WJ)

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Target: NFE2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1D7C8

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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