NPTN

This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants.

neuroplastin

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).
Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470).
Promotes localization of XKR8 at the cell membrane (PubMed:27503893).

Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular calcium ion homeostasisISS:UniProtKB
Dendrite self-avoidanceManual Assertion Based On ExperimentIBA:GO_Central
Excitatory synapse assemblyIEA:Ensembl
Homophilic cell adhesion via plasma membrane adhesion moleculesISS:HGNC-UCL
Long-term synaptic potentiationISS:UniProtKB
Negative regulation of cytokine productionISS:UniProtKB
Positive regulation of cytosolic calcium ion concentrationISS:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Positive regulation of fibroblast growth factor receptor signaling pathwayISS:UniProtKB
Positive regulation of long-term neuronal synaptic plasticityISS:HGNC-UCL
Positive regulation of long-term synaptic potentiationIEA:Ensembl
Positive regulation of neuron projection developmentISS:UniProtKB
Positive regulation of protein localizationIEA:Ensembl
Positive regulation of protein phosphorylationISS:UniProtKB
Regulation of receptor localization to synapseIEA:Ensembl
Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmissionIEA:Ensembl
Visual learningIEA:Ensembl

Cell membrane
Isoform 2
Cell junction, synapse, postsynaptic density

Extracellular: 29-339
Helical: 340-360
Cytoplasmic: 361-398