Human NPTN ELISA Kit (V2LY-0626-LY4951)

Name: Human NPTN ELISA Kit
SKU: V2LY-0626-LY4951
Rating: 5 (1 reviews)

See all NPTN antibodies

Compare Online Inquiry

Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0094 ng/mL

Detection Range

0.02-4.5 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

44.4 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

neuroplastin

Function

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).
Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470).
Promotes localization of XKR8 at the cell membrane (PubMed:27503893).

Biological Process

Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular calcium ion homeostasisISS:UniProtKB
Dendrite self-avoidanceManual Assertion Based On ExperimentIBA:GO_Central
Excitatory synapse assemblyIEA:Ensembl
Homophilic cell adhesion via plasma membrane adhesion moleculesISS:HGNC-UCL
Long-term synaptic potentiationISS:UniProtKB
Negative regulation of cytokine productionISS:UniProtKB
Positive regulation of cytosolic calcium ion concentrationISS:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Positive regulation of fibroblast growth factor receptor signaling pathwayISS:UniProtKB
Positive regulation of long-term neuronal synaptic plasticityISS:HGNC-UCL
Positive regulation of long-term synaptic potentiationIEA:Ensembl
Positive regulation of neuron projection developmentISS:UniProtKB
Positive regulation of protein localizationIEA:Ensembl
Positive regulation of protein phosphorylationISS:UniProtKB
Regulation of receptor localization to synapseIEA:Ensembl
Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmissionIEA:Ensembl
Visual learningIEA:Ensembl

Cellular Location

Cell membrane
Isoform 2
Cell junction, synapse, postsynaptic density

Topology

Extracellular: 29-339
Helical: 340-360
Cytoplasmic: 361-398

Li, S., Wei, X., Huang, H., Ye, L., Ma, M., Sun, L., ... & Wu, Y. (2023). Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors. Journal of Translational Medicine, 21(1), 707.

Chen, J., Lin, X., Bhattacharya, S., Wiesehöfer, C., Wennemuth, G., Müller, K., & Montag, D. (2023). Neuroplastin Expression in Male Mice Is Essential for Fertility, Mating, and Adult Testosterone Levels. International Journal of Molecular Sciences, 25(1), 177.

Newton, S., Kong, F., Carlton, A. J., Aguilar, C., Parker, A., Codner, G. F., ... & Bowl, M. R. (2022). Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing. PLoS Genetics, 18(1), e1009937.

Ilic, K., Mlinac-Jerkovic, K., Sedmak, G., Rosenzweig, I., & Kalanj-Bognar, S. (2021). Neuroplastin in human cognition: review of literature and future perspectives. Translational Psychiatry, 11(1), 394.

Lin, X., Liang, Y., Herrera-Molina, R., & Montag, D. (2021). Neuroplastin in neuropsychiatric diseases. Genes, 12(10), 1507.

Lin, X., Brunk, M. G., Yuanxiang, P., Curran, A. W., Zhang, E., Stöber, F., ... & Montag, D. (2021). Neuroplastin expression is essential for hearing and hair cell PMCA expression. Brain Structure and Function, 226, 1533-1551.

Lin, X. (2021). Significance of neuroplastin and its paralog Basigin for plasma membrane-associated Ca 2+ ATPases in the central and peripheral nervous system.

Yagi, T., Asada, R., Kanekura, K., Eesmaa, A., Lindahl, M., Saarma, M., & Urano, F. (2020). Neuroplastin modulates anti-inflammatory effects of MANF. Iscience, 23(12).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human NPTN ELISA Kit?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant NPTN protein, ECD, His Tag (CAT#: V2LY-0526-LY5829)

Related Products

Mouse Anti-NPTN Recombinant Antibody (2F4) (CAT#: CBMAB-N3267-WJ)

Mouse Anti-NPTN Recombinant Antibody (1B10B5) (CAT#: CBMAB-N3264-WJ)

Mouse Anti-NPTN Recombinant Antibody (1E5) (CAT#: CBMAB-N3263-WJ)

Mouse Anti-NPTN Recombinant Antibody (2D4) (CAT#: CBMAB-N3266-WJ)

Human Recombinant NPTN protein, ECD, His Tag (CAT#: V2LY-0526-LY5829)

Mouse Anti-NPTN Recombinant Antibody (3C4) (CAT#: CBMAB-N3269-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry