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Mouse Anti-NPTN Recombinant Antibody (1E5) (CBMAB-N3263-WJ)

This product is a Mouse antibody that recognizes NPTN. The antibody 1E5 can be used for immunoassay techniques such as: WB, IF .
See all NPTN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E5
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.79 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
neuroplastin
Introduction
This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
Entrez Gene ID
27020
UniProt ID
Q9Y639
Alternative Names
Neuroplastin; Stromal Cell Derived Factor Receptor 1; Stromal Cell-Derived Receptor 1; SDFR1; SDR-1; SDR1;
Function
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).
Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470).
Promotes localization of XKR8 at the cell membrane (PubMed:27503893).
Biological Process
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular calcium ion homeostasisISS:UniProtKB
Dendrite self-avoidanceManual Assertion Based On ExperimentIBA:GO_Central
Excitatory synapse assemblyIEA:Ensembl
Homophilic cell adhesion via plasma membrane adhesion moleculesISS:HGNC-UCL
Long-term synaptic potentiationISS:UniProtKB
Negative regulation of cytokine productionISS:UniProtKB
Positive regulation of cytosolic calcium ion concentrationISS:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Positive regulation of fibroblast growth factor receptor signaling pathwayISS:UniProtKB
Positive regulation of long-term neuronal synaptic plasticityISS:HGNC-UCL
Positive regulation of long-term synaptic potentiationIEA:Ensembl
Positive regulation of neuron projection developmentISS:UniProtKB
Positive regulation of protein localizationIEA:Ensembl
Positive regulation of protein phosphorylationISS:UniProtKB
Regulation of receptor localization to synapseIEA:Ensembl
Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmissionIEA:Ensembl
Visual learningIEA:Ensembl
Cellular Location
Cell membrane
Isoform 2
Cell junction, synapse, postsynaptic density
Topology
Extracellular: 29-339
Helical: 340-360
Cytoplasmic: 361-398

Li, S., Wei, X., Huang, H., Ye, L., Ma, M., Sun, L., ... & Wu, Y. (2023). Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors. Journal of Translational Medicine, 21(1), 707.

Chen, J., Lin, X., Bhattacharya, S., Wiesehöfer, C., Wennemuth, G., Müller, K., & Montag, D. (2023). Neuroplastin Expression in Male Mice Is Essential for Fertility, Mating, and Adult Testosterone Levels. International Journal of Molecular Sciences, 25(1), 177.

Newton, S., Kong, F., Carlton, A. J., Aguilar, C., Parker, A., Codner, G. F., ... & Bowl, M. R. (2022). Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing. PLoS Genetics, 18(1), e1009937.

Ilic, K., Mlinac-Jerkovic, K., Sedmak, G., Rosenzweig, I., & Kalanj-Bognar, S. (2021). Neuroplastin in human cognition: review of literature and future perspectives. Translational Psychiatry, 11(1), 394.

Lin, X., Liang, Y., Herrera-Molina, R., & Montag, D. (2021). Neuroplastin in neuropsychiatric diseases. Genes, 12(10), 1507.

Lin, X., Brunk, M. G., Yuanxiang, P., Curran, A. W., Zhang, E., Stöber, F., ... & Montag, D. (2021). Neuroplastin expression is essential for hearing and hair cell PMCA expression. Brain Structure and Function, 226, 1533-1551.

Lin, X. (2021). Significance of neuroplastin and its paralog Basigin for plasma membrane-associated Ca 2+ ATPases in the central and peripheral nervous system.

Yagi, T., Asada, R., Kanekura, K., Eesmaa, A., Lindahl, M., Saarma, M., & Urano, F. (2020). Neuroplastin modulates anti-inflammatory effects of MANF. Iscience, 23(12).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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