PAPPA
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers.
Full Name
Pappalysin 1
Function
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Biological Process
Cellular protein metabolic processTAS:Reactome
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Response to follicle-stimulating hormoneIEA:Ensembl
Response to glucocorticoidIEA:Ensembl
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Response to follicle-stimulating hormoneIEA:Ensembl
Response to glucocorticoidIEA:Ensembl
Cellular Location
Secreted
PTM
There appear to be no free sulfhydryl groups.
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Anti-PAPPA antibodies
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CompareTarget: PAPPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0627
Application*: E
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1-1
Application*: WB, E, IH, P
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1_1
Application*: E, IH, WB
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYR0737
Application*: SE
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYR0736
Application*: SE
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYR0586
Application*: SE
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYR0585
Application*: SE
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NA
Application*: ELISA, WB, IHC
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1G3
Application*: WB, E
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7A6
Application*: WB, IP, E
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 11E4
Application*: E, IP, WB
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10E1
Application*: WB, IP, E
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10A5
Application*: WB, E
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 100
Application*: WB, E
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1.B.131
Application*: E, IP, WB
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10H9
Application*: E, WB
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10E2
Application*: E
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0626
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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