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PAPPA

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers.
Full Name
Pappalysin 1
Function
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Biological Process
Cellular protein metabolic processTAS:Reactome
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Response to follicle-stimulating hormoneIEA:Ensembl
Response to glucocorticoidIEA:Ensembl
Cellular Location
Secreted
PTM
There appear to be no free sulfhydryl groups.

Anti-PAPPA antibodies

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Mouse Anti-PAPPA Recombinant Antibody (10E2) (CBMAB-A4649-YC)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10E2
Application*: E

Mouse Anti-PAPPA Recombinant Antibody (10H9) (CBMAB-A4650-YC)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10H9
Application*: E, WB

Mouse Anti-PAPPA Recombinant Antibody (1.B.131) (CBMAB-P0748-YC)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1.B.131
Application*: E, IP, WB

Mouse Anti-PAPPA Recombinant Antibody (1_1) (CBMAB-P0749-YC)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1_1
Application*: E, IH, WB

Mouse Anti-PAPPA Recombinant Antibody (100) (CBMAB-P0751-YC)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 100
Application*: WB, E

Mouse Anti-PAPPA Recombinant Antibody (10A5) (CBMAB-P0752-YC)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10A5
Application*: WB, E

Mouse Anti-PAPPA Recombinant Antibody (10E1) (CBMAB-P0753-YC)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10E1
Application*: WB, IP, E

Mouse Anti-PAPPA Recombinant Antibody (1-1) (CBMAB-P0755-YC)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1-1
Application*: WB, E, IH, P

Mouse Anti-PAPPA Recombinant Antibody (11E4) (CBMAB-P0756-YC)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 11E4
Application*: E, IP, WB

Mouse Anti-PAPPA Recombinant Antibody (7A6) (CBMAB-P0758-YC)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7A6
Application*: WB, IP, E

Mouse Anti-PAPPA Recombinant Antibody (1G3) (CBMAB-A6323-LY)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1G3
Application*: WB, E

Mouse Anti-PAPPA Recombinant Antibody (NA) (CBMAB-AO840LY)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NA
Application*: ELISA, WB, IHC

Mouse Anti-PAPPA Monoclonal Antibody (CBFYR0585) (CBMAB-R0585-FY)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYR0585
Application*: SE

Mouse Anti-PAPPA Monoclonal Antibody (CBFYR0586) (CBMAB-R0586-FY)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYR0586
Application*: SE

Mouse Anti-PAPPA Monoclonal Antibody (CBFYR0626) (CBMAB-R0626-FY)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0626
Application*: E

Mouse Anti-PAPPA Monoclonal Antibody (CBFYR0627) (CBMAB-R0627-FY)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0627
Application*: E

Mouse Anti-PAPPA Monoclonal Antibody (CBFYR0736) (CBMAB-R0736-FY)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYR0736
Application*: SE

Mouse Anti-PAPPA Monoclonal Antibody (CBFYR0737) (CBMAB-R0737-FY)

Datasheet SDS
Target: PAPPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYR0737
Application*: SE
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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