Mouse Anti-PAPPA Monoclonal Antibody (CBFYR0585) (CBMAB-R0585-FY)

Name: Mouse Anti-PAPPA Monoclonal Antibody (CBFYR0585)
SKU: CBMAB-R0585-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYR0585

Application

S-ELISA

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.03% Proclin 300

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Pappalysin 1

Introduction

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers.

Entrez Gene ID

5069

UniProt ID

Q13219

Alternative Names

Pappalysin 1; Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease; Pregnancy-Associated Plasma Protein A, Pappalysin 1; Differentially Placenta 1 Expressed Protein; Aspecific BCL2 ARE-Binding Protein 2; IGF-Dependent IGFBP-4 Protease; IGFBP-4ase; PAPP-A; Insulin-Like Growth Factor-Dependent IGF-Binding Protein 4 Protease

Function

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.

Biological Process

Cellular protein metabolic processTAS:Reactome
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Response to follicle-stimulating hormoneIEA:Ensembl
Response to glucocorticoidIEA:Ensembl

Cellular Location

Secreted

PTM

There appear to be no free sulfhydryl groups.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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