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Mouse Anti-PAPPA Recombinant Antibody (10A5) (CBMAB-P0752-YC)

Provided herein is a Mouse monoclonal antibody against Human Pappalysin 1. The antibody can be used for immunoassay techniques, such as WB, ELISA.
See all PAPPA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10A5
Antibody Isotype
IgG2a
Application
WB, ELISA

Basic Information

Immunogen
Purified human PAPPA antigen
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pappalysin 1
Introduction
PAPPA is a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers.
Entrez Gene ID
5069
UniProt ID
Q13219
Alternative Names
Pappalysin 1; Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease; Pregnancy-Associated Plasma Protein A, Pappalysin 1; Differentially Placenta 1 Expressed Protein; Aspecific BCL2 ARE-Binding Protein 2; IGF-Dependent IGFBP-4 Protease; IGFBP-4ase; PAPP-A; Insulin-Like Growth Factor-Dependent IGF-Binding Protein 4 Protease;
Function
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Biological Process
Cellular protein metabolic processTAS:Reactome
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Response to follicle-stimulating hormoneIEA:Ensembl
Response to glucocorticoidIEA:Ensembl
Cellular Location
Secreted
PTM
There appear to be no free sulfhydryl groups.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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