PLS1

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq]

Full Name

plastin 1 (I isoform)

Function

Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions.

Biological Process

Actin filament bundle assemblyManual Assertion Based On ExperimentIBA:GO_Central
Actin filament network formationManual Assertion Based On ExperimentIBA:GO_Central
Auditory receptor cell stereocilium organizationISS:UniProtKB
Intestinal D-glucose absorptionIEA:Ensembl
Positive regulation of multicellular organism growthIEA:Ensembl
Positive regulation of protein localization to plasma membraneISS:UniProtKB
Regulation of microvillus lengthIEA:Ensembl
Terminal web assemblyIEA:Ensembl
Vestibular receptor cell stereocilium organizationISS:UniProtKB

Cellular Location

Cytoplasm
Cell projection, stereocilium

Involvement in disease

Deafness, autosomal dominant, 76 (DFNA76):
A form of non-syndromic deafness characterized by mild to profound sensorineural hearing loss and variable age at onset. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

PTM

Phosphorylated.