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Mouse Anti-PLS1 Recombinant Antibody (3G10) (CBMAB-P2175-YC)

Provided herein is a Mouse monoclonal antibody against Human Plastin 1. The antibody can be used for immunoassay techniques, such as WB.
See all PLS1 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G10
Antibody Isotype
IgG2b, κ
Application
WB

Basic Information

Immunogen
PLS1 (NP_002661, 1-103 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
plastin 1 (I isoform)
Introduction
PLS1 (Plastin 1) is a protein coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology annotations related to this gene includecalcium ion binding and actin filament binding. An important paralog of the gene is PLS3.
Entrez Gene ID
UniProt ID
Alternative Names
Fimbrin; Intestine-Specific Plastin
Function
Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions.
Biological Process
Actin filament bundle assemblyManual Assertion Based On ExperimentIBA:GO_Central
Actin filament network formationManual Assertion Based On ExperimentIBA:GO_Central
Auditory receptor cell stereocilium organizationISS:UniProtKB
Intestinal D-glucose absorptionIEA:Ensembl
Positive regulation of multicellular organism growthIEA:Ensembl
Positive regulation of protein localization to plasma membraneISS:UniProtKB
Regulation of microvillus lengthIEA:Ensembl
Terminal web assemblyIEA:Ensembl
Vestibular receptor cell stereocilium organizationISS:UniProtKB
Cellular Location
Cytoplasm
Cell projection, stereocilium
Involvement in disease
Deafness, autosomal dominant, 76 (DFNA76):
A form of non-syndromic deafness characterized by mild to profound sensorineural hearing loss and variable age at onset. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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