Mouse Anti-PLS1 Recombinant Antibody (3G10) (CBMAB-P2175-YC)

Name: Mouse Anti-PLS1 Recombinant Antibody (3G10)
SKU: CBMAB-P2175-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3G10

Application

Immunogen

PLS1 (NP_002661, 1-103 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

plastin 1 (I isoform)

Introduction

PLS1 (Plastin 1) is a protein coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology annotations related to this gene includecalcium ion binding and actin filament binding. An important paralog of the gene is PLS3.

Entrez Gene ID

5357

UniProt ID

Q14651

Alternative Names

Fimbrin; Intestine-Specific Plastin

Function

Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions.

Biological Process

Actin filament bundle assemblyManual Assertion Based On ExperimentIBA:GO_Central
Actin filament network formationManual Assertion Based On ExperimentIBA:GO_Central
Auditory receptor cell stereocilium organizationISS:UniProtKB
Intestinal D-glucose absorptionIEA:Ensembl
Positive regulation of multicellular organism growthIEA:Ensembl
Positive regulation of protein localization to plasma membraneISS:UniProtKB
Regulation of microvillus lengthIEA:Ensembl
Terminal web assemblyIEA:Ensembl
Vestibular receptor cell stereocilium organizationISS:UniProtKB

Cellular Location

Cytoplasm
Cell projection, stereocilium

Involvement in disease

Deafness, autosomal dominant, 76 (DFNA76):
A form of non-syndromic deafness characterized by mild to profound sensorineural hearing loss and variable age at onset. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

PTM

Phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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