POLR3C

POLR3C (RNA Polymerase III Subunit C) is a protein coding gene. Diseases associated with POLR3C include Chickenpox. Among its related pathways are RNA Polymerase III Transcription Initiation and Pyrimidine metabolism (KEGG). Gene Ontology annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase III activity.

Full Name

RNA Polymerase III Subunit C

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628).

Biological Process

Defense response to virusIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Positive regulation of innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interferon-beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription by RNA polymerase IIIManual Assertion Based On ExperimentTAS:ProtInc
Transcription, DNA-templatedIEA:InterPro

Cellular Location

Nucleus