PPP4C

PPP4C (Protein Phosphatase 4 Catalytic Subunit) is a protein coding gene. Among its related pathways are DNA Double-Strand Break Repair and Glucagon signaling pathway. Gene Ontology annotations related to this gene include hydrolase activity and protein serine/threonine phosphatase activity.

Full Name

Protein Phosphatase 4 Catalytic Subunit

Function

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity).
In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Biological Process

Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of histone phosphorylationManual Assertion Based On ExperimentIMP:ComplexPortal
Protein dephosphorylationIEA:UniProt
Regulation of double-strand break repairManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

PTM

Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.