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Mouse Anti-PPP4C Recombinant Antibody (CB02A) (CBMAB-CA002LY)


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Summary

Host Animal
Mouse
Specificity
Human, Dog, Mouse, Cattle, Rat
Clone
CB02A
Antibody Isotype
IgG2a
Application
ELISA, WB, IHC, ICC

Basic Information

Immunogen
Recombinant full length protein (307aa) of Human PPP4C.
Specificity
Human, Dog, Mouse, Cattle, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Protein Phosphatase 4 Catalytic Subunit
Entrez Gene ID
Human5531
Mouse56420
Rat171366
Cattle540398
Dog489947
UniProt ID
HumanP60510
MouseP97470
RatQ5BJ92
CattleA6H772
DogE2QU52
Function
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity).
In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Biological Process
Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of histone phosphorylationManual Assertion Based On ExperimentIMP:ComplexPortal
Protein dephosphorylationIEA:UniProt
Regulation of double-strand break repairManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
PTM
Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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