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Mouse Anti-PPP4C Recombinant Antibody (CBYC-P580) (CBMAB-P2659-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P580
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived Recombinant human PP4 Catalytic Subunit, Met1-Leu307
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized from PBS with trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Phosphatase 4 Catalytic Subunit
Introduction
PPP4C (Protein Phosphatase 4 Catalytic Subunit) is a protein coding gene. Among its related pathways are DNA Double-Strand Break Repair and Glucagon signaling pathway. Gene Ontology annotations related to this gene include hydrolase activity and protein serine/threonine phosphatase activity.
Entrez Gene ID
5531
UniProt ID
P60510
Alternative Names
PPP4; PP-X; PPH3; PP4; PP4C; PPX
Function
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity).
In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Biological Process
Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of histone phosphorylationManual Assertion Based On ExperimentIMP:ComplexPortal
Protein dephosphorylationIEA:UniProt
Regulation of double-strand break repairManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
PTM
Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
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For research use only. Not intended for any clinical use.

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