PROK1

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) induces proliferation, migration, and fenestration in capillary endothelial cells derived from endocrine glands. Its expression is induced by hypoxia and is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta). Its expression is often complementary to the expression of VEGF (MIM 192240), suggesting that these molecules function in a coordinated manner.[supplied by OMIM
Full Name
prokineticin 1
Function
Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.
Biological Process
AngiogenesisIEA:UniProtKB-KW
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of vascular endothelial cell proliferationIEA:Ensembl
Regulation of angiogenesisIEA:Ensembl
Vascular endothelial cell proliferationIEA:Ensembl
Cellular Location
Secreted
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Anti-PROK1 antibodies

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Mouse Anti-PROK1 Recombinant Antibody (3C3) (CBMAB-A7079-LY)

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Target: PROK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3C3
Application*: SE, E
Datasheet SDS

Mouse Anti-PROK1 Recombinant Antibody (CBYC-P651) (CBMAB-P2983-YC)

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Target: PROK1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P651
Application*: WB, IC, P, C, E
Datasheet SDS

Rabbit Anti-PROK1 Recombinant Antibody (CBYC-P650) (CBMAB-P2982-YC)

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Target: PROK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYC-P650
Application*: WB, F
Datasheet SDS

Mouse Anti-PROK1 Recombinant Antibody (2L13) (CBMAB-P2981-YC)

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Target: PROK1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human, Mouse, Rat
Clone: 2L13
Application*: WB, E, P
Datasheet SDS

Mouse Anti-PROK1 Recombinant Antibody (CBFYE-1609) (CBMAB-E2268-FY)

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Target: PROK1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human, Mouse, Rat
Clone: CBFYE-1609
Application*: E, IH, WB
Datasheet SDS

Human PROK1 ELISA Kit (V2LY-0626-LY4089)

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Target: PROK1
Sensitivity: 0.046 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant PROK1 protein, His Tag (V2LY-0526-LY6335)

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Target: PROK1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-105
Tag: His Tag
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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