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PROK1

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) induces proliferation, migration, and fenestration in capillary endothelial cells derived from endocrine glands. Its expression is induced by hypoxia and is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta). Its expression is often complementary to the expression of VEGF (MIM 192240), suggesting that these molecules function in a coordinated manner.[supplied by OMIM

Full Name

prokineticin 1

Function

Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.

Biological Process

AngiogenesisIEA:UniProtKB-KW
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of vascular endothelial cell proliferationIEA:Ensembl
Regulation of angiogenesisIEA:Ensembl
Vascular endothelial cell proliferationIEA:Ensembl

Cellular Location

Secreted

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Anti-PROK1 antibodies

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Mouse Anti-PROK1 Recombinant Antibody (3C3) (CBMAB-A7079-LY)

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Target: PROK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3C3

Application*: SE, E

Mouse Anti-PROK1 Recombinant Antibody (CBYC-P651) (CBMAB-P2983-YC)

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Target: PROK1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-P651

Application*: WB, IC, P, C, E

Rabbit Anti-PROK1 Recombinant Antibody (CBYC-P650) (CBMAB-P2982-YC)

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Target: PROK1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBYC-P650

Application*: WB, F

Mouse Anti-PROK1 Recombinant Antibody (2L13) (CBMAB-P2981-YC)

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Target: PROK1

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human, Mouse, Rat

Clone: 2L13

Application*: WB, E, P

Mouse Anti-PROK1 Recombinant Antibody (CBFYE-1609) (CBMAB-E2268-FY)

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Target: PROK1

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human, Mouse, Rat

Clone: CBFYE-1609

Application*: E, IH, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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