PTK7

Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq]
Full Name
protein tyrosine kinase 7
Function
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Axis elongationIEA:Ensembl
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to retinoic acidManual Assertion Based On ExperimentIMP:BHF-UCL
Cochlea morphogenesisIEA:Ensembl
Convergent extensionIEA:Ensembl
Coronary vasculature developmentIEA:Ensembl
Establishment of epithelial cell apical/basal polarityIEA:Ensembl
Establishment of planar polarityIEA:Ensembl
Kidney developmentIEA:Ensembl
Lung-associated mesenchyme developmentIEA:Ensembl
Planar cell polarity pathway involved in neural tube closureIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Protein phosphorylationIEA:InterPro
Regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Ventricular septum developmentIEA:Ensembl
Wound healingIEA:Ensembl
Cellular Location
Membrane
Cell junction
Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
Topology
Extracellular: 31-704
Helical: 705-725
Cytoplasmic: 726-1070
PTM
MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
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Anti-PTK7 antibodies

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Mouse Anti-PTK7 Recombinant Antibody (CBYC-P770) (CBMAB-P3392-YC)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYC-P770
Application*: F
Datasheet SDS

Rabbit Anti-PTK7 Recombinant Antibody (D2Z1N) (CBMAB-CP0157-LY)

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Target: PTK7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D2Z1N
Application*: WB, IP
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (4F5) (CBMAB-A7204-LY)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4F5
Application*: WB, E
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (4D4) (CBMAB-A7203-LY)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4D4
Application*: WB, E
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (4A6) (CBMAB-A7201-LY)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A6
Application*: WB, E
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (1A8) (CBMAB-P3389-YC)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1A8
Application*: E, WB
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (188B) (CBMAB-P3388-YC)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 188B
Application*: F
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (CBYY-C2739) (CBMAB-C4180-YY)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C2739
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (CBFYC-3054) (CBMAB-C3131-FY)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-3054
Application*: WB
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (4F9) (CBMAB-C6959-LY)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4F9
Application*: WB, E, P
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (4C6) (CBMAB-C6738-LY)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4C6
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (2H4) (CBMAB-C5269-LY)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H4
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (1G4) (CBMAB-C4173-LY)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G4
Application*: WB
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (CBT267) (V2LY-0625-LY3652)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT267
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-PTK7 Recombinant Antibody (CBT2160) (V2LY-0625-LY2455)

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Target: PTK7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2160
Application*: WB, IH
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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