Mouse Anti-PTK7 Recombinant Antibody (4D4) (CBMAB-A7203-LY)

Name: Mouse Anti-PTK7 Recombinant Antibody (4D4)
SKU: CBMAB-A7203-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4D4

Application

WB, ELISA

Immunogen

PTK7 (NP_002812, 36 a.a. ~ 145 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

protein tyrosine kinase 7

Introduction

Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq]

Entrez Gene ID

5754

UniProt ID

Q13308

Alternative Names

CCK4

Function

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Axis elongationIEA:Ensembl
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to retinoic acidManual Assertion Based On ExperimentIMP:BHF-UCL
Cochlea morphogenesisIEA:Ensembl
Convergent extensionIEA:Ensembl
Coronary vasculature developmentIEA:Ensembl
Establishment of epithelial cell apical/basal polarityIEA:Ensembl
Establishment of planar polarityIEA:Ensembl
Kidney developmentIEA:Ensembl
Lung-associated mesenchyme developmentIEA:Ensembl
Planar cell polarity pathway involved in neural tube closureIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Protein phosphorylationIEA:InterPro
Regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Ventricular septum developmentIEA:Ensembl
Wound healingIEA:Ensembl

Cellular Location

Membrane
Cell junction
Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.

Topology

Extracellular: 31-704
Helical: 705-725
Cytoplasmic: 726-1070

PTM

MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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