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Mouse Anti-PTK7 Recombinant Antibody (1A8) (CBMAB-P3389-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine kinase 7 (inactive). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PTK7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A8
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PTK7 (NP_002812, 36-145 aa) partial recombinant protein with GST tag. Immunogen sequence: KQPSSQDALQ GRRALLRCEV EAPGPVHVYW LLDGAPVQDT ERRFAQGSSL SFAAVDRLQD SGTFQCVARD DVTGEEARSA NASFNIKWIE AGPVVLKHPA SEAEIQPQTQ
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein tyrosine kinase 7
Introduction
PTK7 is a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion.
Entrez Gene ID
5754
UniProt ID
Q13308
Alternative Names
CCK4; CCK-4
Function
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Axis elongationIEA:Ensembl
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to retinoic acidManual Assertion Based On ExperimentIMP:BHF-UCL
Cochlea morphogenesisIEA:Ensembl
Convergent extensionIEA:Ensembl
Coronary vasculature developmentIEA:Ensembl
Establishment of epithelial cell apical/basal polarityIEA:Ensembl
Establishment of planar polarityIEA:Ensembl
Kidney developmentIEA:Ensembl
Lung-associated mesenchyme developmentIEA:Ensembl
Planar cell polarity pathway involved in neural tube closureIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Protein phosphorylationIEA:InterPro
Regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Ventricular septum developmentIEA:Ensembl
Wound healingIEA:Ensembl
Cellular Location
Membrane
Cell junction
Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
Topology
Extracellular: 31-704
Helical: 705-725
Cytoplasmic: 726-1070
PTM
MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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