Human Recombinant PTK7 protein, His Tag (V2LY-0526-LY2622)

Name: Human Recombinant PTK7 protein, His Tag
SKU: V2LY-0526-LY2622
Rating: 5 (1 reviews)

See all PTK7 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant PTK7 protein, His Tag consist of Amino Acid: 1-704 and predicts a molecular mass of 76.1 kDa.

Molecule Mass

76.1 kDa

Sequence

Amino Acid: 1-704

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

Tris, NaCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

protein tyrosine kinase 7

Function

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Axis elongationIEA:Ensembl
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to retinoic acidManual Assertion Based On ExperimentIMP:BHF-UCL
Cochlea morphogenesisIEA:Ensembl
Convergent extensionIEA:Ensembl
Coronary vasculature developmentIEA:Ensembl
Establishment of epithelial cell apical/basal polarityIEA:Ensembl
Establishment of planar polarityIEA:Ensembl
Kidney developmentIEA:Ensembl
Lung-associated mesenchyme developmentIEA:Ensembl
Planar cell polarity pathway involved in neural tube closureIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Protein phosphorylationIEA:InterPro
Regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Ventricular septum developmentIEA:Ensembl
Wound healingIEA:Ensembl

Cellular Location

Membrane
Cell junction
Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.

Topology

Extracellular: 31-704
Helical: 705-725
Cytoplasmic: 726-1070

PTM

MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant PTK7 protein, His Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant PTK7 protein, GST Tag (CAT#: V2LY-0526-LY2621)

Human Recombinant PTK7 protein, His Tag-1 (CAT#: V2LY-0526-LY2623)

Cynomolgus, Rhesus Recombinant PTK7 protein, His Tag (CAT#: V2LY-0526-LY1685)

Related Products

Mouse Anti-PTK7 Recombinant Antibody (CBFYC-3054) (CAT#: CBMAB-C3131-FY)

Mouse Anti-PTK7 Recombinant Antibody (4F9) (CAT#: CBMAB-C6959-LY)

Mouse Anti-PTK7 Recombinant Antibody (188B) (CAT#: CBMAB-P3388-YC)

Mouse Anti-PTK7 Recombinant Antibody (CBYY-C2739) (CAT#: CBMAB-C4180-YY)

Mouse Anti-PTK7 Recombinant Antibody (CBT267) (CAT#: V2LY-0625-LY3652)

Mouse Anti-PTK7 Recombinant Antibody (4A6) (CAT#: CBMAB-A7201-LY)

Rabbit Anti-PTK7 Recombinant Antibody (D2Z1N) (CAT#: CBMAB-CP0157-LY)

Mouse Anti-PTK7 Recombinant Antibody (CBYC-P770) (CAT#: CBMAB-P3392-YC)

Mouse Anti-PTK7 Recombinant Antibody (4F5) (CAT#: CBMAB-A7204-LY)

Cynomolgus, Rhesus Recombinant PTK7 protein, His Tag (CAT#: V2LY-0526-LY1685)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry