RAP1GAP

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]

RAP1 GTPase Activating Protein

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adaptive immune responseTAS:Reactome
Biological Process cellular response to glial cell derived neurotrophic factorIEA:Ensembl
Biological Process negative regulation of GTP bindingIEA:Ensembl
Biological Process negative regulation of microvillus assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of neuron differentiationIEA:Ensembl
Biological Process negative regulation of thyroid gland epithelial cell proliferationIEA:Ensembl
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionIEA:InterPro
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Golgi apparatus membrane