Rabbit Anti-RAP1GAP Recombinant Antibody (7i55) (CBMAB-R1317-CN)

Name: Rabbit Anti-RAP1GAP Recombinant Antibody (7i55)
SKU: CBMAB-R1317-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

7i55

Application

WB, IP, IHC, FC, IF

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50mM Tris-Glycine, pH 7.4, 0.15M NaCl, 0.05% BSA, 40% Glycerol

Preservative

0.01% Sodium azide

More Infomation

Target

Full Name

RAP1 GTPase Activating Protein

Introduction

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]

Entrez Gene ID

Human	5909
Mouse	110351
Rat	313644

UniProt ID

Human	P47736
Mouse	A2ALS5
Rat	Q5EB70

Alternative Names

RAP1 GTPase Activating Protein; RAP1GAP1; RAP1GA1; RAP1, GTPase Activating Protein 1; Rap1 GTPase-Activating Protein 1; RAP1GAPII; KIAA0474; Rap1GAP; RAPGAP;

Function

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

Biological Process

Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adaptive immune responseTAS:Reactome
Biological Process cellular response to glial cell derived neurotrophic factorIEA:Ensembl
Biological Process negative regulation of GTP bindingIEA:Ensembl
Biological Process negative regulation of microvillus assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of neuron differentiationIEA:Ensembl
Biological Process negative regulation of thyroid gland epithelial cell proliferationIEA:Ensembl
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionIEA:InterPro
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Golgi apparatus membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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