Sign in or Register   Sign in or Register
  |  

Mouse Anti-RAP1GAP Recombinant Antibody (2G7B6) (CBMAB-R1315-CN)

This product is a Mouse antibody that recognizes RAP1GAP. The antibody 2G7B6 can be used for immunoassay techniques such as: WB, FC.
See all RAP1GAP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G7B6
Antibody Isotype
IgG2b
Application
WB, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
RAP1 GTPase Activating Protein
Introduction
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Entrez Gene ID
5909
UniProt ID
P47736
Alternative Names
RAP1 GTPase Activating Protein; RAP1GAP1; RAP1GA1; RAP1, GTPase Activating Protein 1; Rap1 GTPase-Activating Protein 1; RAP1GAPII; KIAA0474; Rap1GAP; RAPGAP;
Function
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Biological Process
Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adaptive immune responseTAS:Reactome
Biological Process cellular response to glial cell derived neurotrophic factorIEA:Ensembl
Biological Process negative regulation of GTP bindingIEA:Ensembl
Biological Process negative regulation of microvillus assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of neuron differentiationIEA:Ensembl
Biological Process negative regulation of thyroid gland epithelial cell proliferationIEA:Ensembl
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionIEA:InterPro
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Golgi apparatus membrane
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-RAP1GAP Recombinant Antibody (2G7B6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare