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Rabbit Anti-RAP1GAP Recombinant Antibody (Y134) (CBMAB-R0107-CN)

This product is a Rabbit antibody that recognizes RAP1GAP. The antibody Y134 can be used for immunoassay techniques such as: WB, IP, IHC-P, ICC, FC, IF.
See all RAP1GAP antibodies
Published Data
Fig.1 SPOCK2 and PTRF/CAVIN-1 proteins increase in transitioning hAT2 cells on collagen over 10 days, while Rap1GAP is expressed mainly in AT2 cells on Matrigel.
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Fig.2 IF studies demonstrated strongly increased expression of RAP1GAP in podocytes of Tg26 mice as determined by colocalization with the podocyte-specific cytoplasmic protein nestin.
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Fig.3 Increased podocyte expression of RAP1GAP drives podocyte injury by preventing activation of β1 integrin.
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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
Y134
Antibody Isotype
IgG
Application
WB, IP, IHC-P, ICC, FC, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
RAP1 GTPase Activating Protein
Introduction
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Entrez Gene ID
Human5909
Mouse110351
Rat313644
UniProt ID
HumanP47736
MouseA2ALS5
RatQ5EB70
Alternative Names
RAP1 GTPase Activating Protein; RAP1GAP1; RAP1GA1; RAP1, GTPase Activating Protein 1; Rap1 GTPase-Activating Protein 1; RAP1GAPII; KIAA0474; Rap1GAP; RAPGAP;
Function
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Biological Process
Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adaptive immune responseTAS:Reactome
Biological Process cellular response to glial cell derived neurotrophic factorIEA:Ensembl
Biological Process negative regulation of GTP bindingIEA:Ensembl
Biological Process negative regulation of microvillus assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of neuron differentiationIEA:Ensembl
Biological Process negative regulation of thyroid gland epithelial cell proliferationIEA:Ensembl
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionIEA:InterPro
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Golgi apparatus membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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