RPS6KA6

This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
Full Name
ribosomal protein S6 kinase, 90kDa, polypeptide 6
Function
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
Biological Process
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of embryonic developmentISS:UniProtKB
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process negative regulation of mesoderm developmentISS:UniProtKB
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm, cytosol
Nucleus
Predominantly cytosolic.
PTM
Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.
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Anti-RPS6KA6 antibodies

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Mouse Anti-RPS6KA6 Recombinant Antibody (CBCNR-834) (CBMAB-R3574-CN)

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Target: RPS6KA6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Human
Clone: CBCNR-834
Application*: WB, P
Datasheet SDS

Mouse Anti-RPS6KA6 Recombinant Antibody (CBCNR-779) (CBMAB-R3572-CN)

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Target: RPS6KA6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: CBCNR-779
Application*: E, WB
Datasheet SDS

Mouse Anti-RPS6KA6 Recombinant Antibody (8J141) (CBMAB-R3571-CN)

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Target: RPS6KA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8J141
Application*: DB, WB
Datasheet SDS

Rat Anti-RPS6KA6 Recombinant Antibody (7H159) (CBMAB-R3567-CN)

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Target: RPS6KA6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H159
Application*: WB
Datasheet SDS

Mouse Anti-RPS6KA6 Recombinant Antibody (6F2) (CBMAB-R3566-CN)

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Target: RPS6KA6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 6F2
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-RPS6KA6 Recombinant Antibody (3A1) (CBMAB-R3563-CN)

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Target: RPS6KA6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3A1
Application*: E, WB
Datasheet SDS

Rat Anti-RPS6KA6 Recombinant Antibody (374521) (CBMAB-R3562-CN)

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Target: RPS6KA6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 374521
Application*: WB
Datasheet SDS

rabbit Anti-RPS6KA6 Recombinant Antibody (10F661) (CBMAB-R3561-CN)

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Target: RPS6KA6
Host: rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 10F661
Application*: F, ICC, IH, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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