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Mouse Anti-RPS6KA6 Recombinant Antibody (CBCNR-779) (CBMAB-R3572-CN)

This product is a Mouse antibody that recognizes RPS6KA6. The antibody CBCNR-779 can be used for immunoassay techniques such as: ELISA, WB.
See all RPS6KA6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBCNR-779
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
RPS6KA6 (NP_055311.1, aa. 636-745) partial recombinant protein with GST tag
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1× PBS, pH 7.2

Target

Full Name
ribosomal protein S6 kinase, 90kDa, polypeptide 6
Introduction
This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
Entrez Gene ID
Human27330
Rat317203
UniProt ID
HumanQ9UK32
RatF1LYL8
Alternative Names
Ribosomal Protein S6 Kinase A6; 90 KDa Ribosomal Protein S6 Kinase 6; Ribosomal S6 Kinase 4; S6K-Alpha-6; EC 2.7.11.1; P90-RSK 6; PP90RSK4; P90RSK6;
Function
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
Biological Process
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of embryonic developmentISS:UniProtKB
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process negative regulation of mesoderm developmentISS:UniProtKB
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm, cytosol
Nucleus
Predominantly cytosolic.
PTM
Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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