Mouse Anti-RPS6KA6 Recombinant Antibody (CBCNR-834) (CBMAB-R3574-CN)

Name: Mouse Anti-RPS6KA6 Recombinant Antibody (CBCNR-834)
SKU: CBMAB-R3574-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBCNR-834

Application

WB, IHC-P

Specificity

Rat, Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

ribosomal protein S6 kinase, 90kDa, polypeptide 6

Introduction

This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]

Entrez Gene ID

Human	27330
Rat	317203

UniProt ID

Human	Q9UK32
Rat	F1LYL8

Alternative Names

Ribosomal Protein S6 Kinase A6; 90 KDa Ribosomal Protein S6 Kinase 6; Ribosomal S6 Kinase 4; S6K-Alpha-6; EC 2.7.11.1; P90-RSK 6; PP90RSK4; P90RSK6;

Function

Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.

Biological Process

Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of embryonic developmentISS:UniProtKB
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process negative regulation of mesoderm developmentISS:UniProtKB
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm, cytosol
Nucleus
Predominantly cytosolic.

PTM

Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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