RTN3

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
Full Name
Reticulon 3
Function
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).
Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIG-I/DDX58, subsequently impairing DDX58 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.
(Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endoplasmic reticulum tubular network formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endoplasmic reticulum tubular network organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle-mediated transportIEA:UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
Topology
Extracellular: 2-863
Helical: 864-887
Cytoplasmic: 888-947
Helical: 948-968
Extracellular: 969-972
Helical: 973-993
Cytoplasmic: 994-1032
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Anti-RTN3 antibodies

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Mouse Anti-RTN3 Recombinant Antibody (CBCNR-850) (CBMAB-R3806-CN)

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Target: RTN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNR-850
Application*: E, P, C
Datasheet SDS

Mouse Anti-RTN3 Recombinant Antibody (3B5) (CBMAB-R3805-CN)

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Target: RTN3
Host: Mouse
Specificity: Human
Clone: 3B5
Application*: IH, E
Datasheet SDS

Mouse Anti-RTN3 Recombinant Antibody (1E11) (CBMAB-R3804-CN)

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Target: RTN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1E11
Application*: E, IF
Datasheet SDS

Mouse Anti-RTN3 Recombinant Antibody (13B687) (CBMAB-R3803-CN)

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Target: RTN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13B687
Application*: E
Datasheet SDS

Mouse Anti-RTN3 Recombinant Antibody (13B686) (CBMAB-R3802-CN)

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Target: RTN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13B686
Application*: E, IH
Datasheet SDS

Mouse Anti-RTN3 Recombinant Antibody (10A8) (CBMAB-R3801-CN)

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Target: RTN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10A8
Application*: E, P
Datasheet SDS

Mouse Anti-RTN3 Recombinant Antibody (CBT1109) (V2LY-0625-LY3026)

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Target: RTN3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1109
Application*: P, IF, E
Datasheet SDS

Mouse Anti-RTN3 Recombinant Antibody (CBT1110) (V2LY-0625-LY3025)

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Target: RTN3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1110
Application*: IF, IC, E
Datasheet SDS

Mouse Anti-RTN3 Recombinant Antibody (CBT4013) (V2LY-0625-LY2311)

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Target: RTN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4013
Application*: IH
Datasheet SDS

Mouse Anti-RTN3 Recombinant Antibody (CBT2524) (V2LY-0625-LY2301)

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Target: RTN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2524
Application*: IC
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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