Mouse Anti-RTN3 Recombinant Antibody (13B686) (CBMAB-R3802-CN)

Name: Mouse Anti-RTN3 Recombinant Antibody (13B686)
SKU: CBMAB-R3802-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

13B686

Application

ELISA, IHC

Immunogen

Purified recombinant fragment of RTN3 expressed in E. coli

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

Ascites

Preservative

0.03% Sodium azide

More Infomation

Target

Full Name

Reticulon 3

Introduction

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]

Entrez Gene ID

10313

UniProt ID

O95197

Alternative Names

Reticulon 3; Neuroendocrine-Specific Protein-Like 2; Homolog Of ASY Protein; NSP-Like Protein II; Neuroendocrine-Specific Protein-Like II; ASY Interacting Protein; NSP-Like Protein 2; NSPLII;

Function

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).
Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIG-I/DDX58, subsequently impairing DDX58 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.
(Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endoplasmic reticulum tubular network formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endoplasmic reticulum tubular network organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle-mediated transportIEA:UniProtKB-KW

Cellular Location

Endoplasmic reticulum membrane
Golgi apparatus membrane

Topology

Extracellular: 2-863
Helical: 864-887
Cytoplasmic: 888-947
Helical: 948-968
Extracellular: 969-972
Helical: 973-993
Cytoplasmic: 994-1032

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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