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Mouse Anti-RTN3 Recombinant Antibody (3B5) (CBMAB-R3805-CN)

This product is a Mouse antibody that recognizes RTN3. The antibody 3B5 can be used for immunoassay techniques such as: IHC, ELISA.
See all RTN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B5
Application
IHC, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Ascites
Preservative
0.03% Sodium azide
Concentration
1 mg/mL

Target

Full Name
Reticulon 3
Introduction
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
Entrez Gene ID
10313
UniProt ID
O95197
Alternative Names
Reticulon 3; Neuroendocrine-Specific Protein-Like 2; Homolog Of ASY Protein; NSP-Like Protein II; Neuroendocrine-Specific Protein-Like II; ASY Interacting Protein; NSP-Like Protein 2; NSPLII;
Function
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).
Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIG-I/DDX58, subsequently impairing DDX58 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.
(Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endoplasmic reticulum tubular network formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endoplasmic reticulum tubular network organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle-mediated transportIEA:UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
Topology
Extracellular: 2-863
Helical: 864-887
Cytoplasmic: 888-947
Helical: 948-968
Extracellular: 969-972
Helical: 973-993
Cytoplasmic: 994-1032
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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