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Mouse Anti-RTN3 Recombinant Antibody (CBT2524) (V2LY-0625-LY2301)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2524
Antibody Isotype
IgG2a
Application
ICC

Basic Information

Immunogen
Purified recombinant fragment of RTN3 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ICC1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Reticulon 3
Entrez Gene ID
10313
Function
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).
Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIG-I/DDX58, subsequently impairing DDX58 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.
(Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endoplasmic reticulum tubular network formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endoplasmic reticulum tubular network organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle-mediated transportIEA:UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
Topology
Extracellular: 2-863
Helical: 864-887
Cytoplasmic: 888-947
Helical: 948-968
Extracellular: 969-972
Helical: 973-993
Cytoplasmic: 994-1032
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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