S. cerevisiae TUP1

Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.

Full Name

chromatin-silencing transcriptional regulator TUP1

Function

Biological Process

Biological Process carbon catabolite repression of transcription from RNA polymerase II promoter by glucoseManual Assertion Based On ExperimentIMP:SGD
Biological Process histone exchangeManual Assertion Based On ExperimentIMP:SGD
Biological Process hyperosmotic responseManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of single-species biofilm formationManual Assertion Based On ExperimentIDA:SGD
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of flocculationManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of invasive growth in response to glucose limitationManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of response to DNA damage stimulusManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:SGD

Cellular Location

Nucleus