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Mouse Anti-S. cerevisiae TUP1 Recombinant Antibody (CBMC-C1142) (CBMAB-V208-1326-CQ)

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Datasheet
SDS
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Basic Information

Host Animal
Mouse
Clone
CBMC-C1142
Application
WB
Immunogen
Recombinant fragment, corresponding to amino acids 1-200 of Saccharomyces cerevisiae TUP1
Specificity
S. cerevisiae
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
chromatin-silencing transcriptional regulator TUP1
Introduction
Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
Entrez Gene ID
850445
UniProt ID
P16649
Alternative Names
TUP1; chromatin-silencing transcriptional regulator TUP1; AAR1; AER2; AMM1; CRT4; CYC9; FLK1; ROX4; SFL2; UMR7
Function
Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
Biological Process
Biological Process carbon catabolite repression of transcription from RNA polymerase II promoter by glucoseManual Assertion Based On ExperimentIMP:SGD
Biological Process histone exchangeManual Assertion Based On ExperimentIMP:SGD
Biological Process hyperosmotic responseManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of single-species biofilm formationManual Assertion Based On ExperimentIDA:SGD
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of flocculationManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of invasive growth in response to glucose limitationManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of response to DNA damage stimulusManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:SGD
Cellular Location
Nucleus
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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